BACKGROUND Right ventricular (RV) pacing generates regional disparities in electrical activation and mechanical function (ventricular dyssynchrony). In contrast, left ventricular (LV) or biventricular (BIV) pacing can improve cardiac efficiency in the setting of ventricular dyssynchrony, constituting the rationale for cardiac resynchronization therapy (CRT). Animal models of ventricular dyssync...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main source(s): National Institute for Research Metabolic and Cardiovascular Diseases, Programme EXCELES, Ministry Health the Czech Republic, grant number NU21-02-00584. Introduction Biventricular pacing (BiV) is an established treatment patients with heart failure dyssynchronous ventricular activation. Lef...

We developed a strategy to create novel genetically encoded switches based on translational repression. We illustrated its efficacy by incorporating two copies of an RNA hairpin in the 5'-untranslated region (UTR) of a target mRNA and demonstrating 7-fold translational repression upon expression of a ligand - the BIV Tat peptide.

This study explores the use of interventricular asynchrony (interVA) for optimizing cardiac resynchronization therapy (CRT), an idea emerging from a simple pathway model of conduction in the ventricles. Measurements were performed in six dogs with chronic left bundle branch block (LBBB) and in 29 patients of the Pacing Therapies for Congestive Heart Failure (PATH-CHF)-I study. In the dogs, intr...

Jembrana disease virus (JDV) is a newly identified bovine lentivirus that is closely related to the bovine immunodeficiency virus (BIV). JDV contains a tat gene, encoded by two exons, which has potent transactivation activity. Cotransfection of the JDV tat expression plasmid with the JDV promoter chloramphenicol acetyltransferase (CAT) construct pJDV-U3R resulted in a substantial increase in th...

Context: Studies have shown that various Assemblages, sub-assemblage (subtypes) and genotypes of Giardia intestinalis multiple hosts; therefore, their distribution reservoirs as well pattern epidemiological are different. The present study was conducted to summarize the results genetic studies on G. in Iran. Evidence Acquisition: To investigate articles Iran, a systematic search Persian English...

Latar belakang: Penelitian ini bertujuan membandingkan pengaruh fotokoagulasi laser dan bevacizumab intravitreal (BIV) terhadap penanda biologis stres oksidatif, antara lain aktivitas aldehid dehidrogenase (ALDH) plasma, kadar malondialdehid (MDA), aktivitas superoxide dismutase (SOD) dan kadar vitreal vascular endothelial growth factor (VEGF) pada penyandang retinopati diabetik (RD) proliferatif.