The methanol extract of the dried aerial parts of Prangos tschimganica gave three new coumarin derivatives and 30 known coumarin derivatives. Their structures were established on the basis of chemical and spectroscopic evidence. Absolute configuration of the isolated compounds were determined by using a modified Mosher's method. Some of the isolated compounds showed anti-HIV activity.

The present article describes the evaluation of the in vitro activity against M. tuberculosis H37Rv of eight coumarin-derived aminoalcohols and amidoamines. Seven of the compounds display activity between 10 and 20 times higher than the classicall anti-TB drug ethambutol. The combination of coumarin scaffold with aminoalcohol fragments gave the most promising activities with MICs up to 0.32 μM.

During the last 2 decades, the study of the biological activities of Coumarin derivatives has been the aim of many researchers. Based on these findings, a series of Coumarin substituted benzothiazoles were synthesized by refluxing Coumarin-4-carboxaldehyde and oaminothiophenol in acetic acid. Compounds were characterized by IR, 1H NMR and mass spectroscopy. All the compounds were tested for the...

The present study evaluated the antioxidant potential of 28 coumarin derivatives, using three antioxidant assays: DPPH inhibition, total reducing power and NO inhibition. Out of the tested compounds, the most active DPPH free radicals scavengers were the coumarin hydrazide derivatives. These substances were also the only ones among the investigated derivatives that exhibited a moderate reducing...

The effect of three aromatic amines namely aniline (AN), dimethyl aniline (DMAN) and diethyl aniline (DEAN) on emission properties of a coumarin derivative 6-methyl-3azidoacetyl coumarin (6M3AAC) in acetonitrile was studied by means of steady state fluorescence spectroscopy. The quenching of fluorescence intensity was observed in the presence of amines. The quenching process was characterized b...

The parallel solution-phase synthesis of a new combinatorial library of 3-[4-(R1-coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acid amides 9 has been developed. The synthesis involves two steps: 1) the synthesis of core building blocks - 3- [4-(coumarin-3-yl)-1,3-thiazol-2-ylcarbamoyl]propanoic acids, 6 - by the reaction of 3-(omega-bromacetyl)coumarins 1 with 3-amino(thioxo)methylcarbamoy...

[Structure: see text] The versatility of supramolecular chemistry has been exploited in constructing nanovalves based on mesoporous silica MCM-41 and the mutual recognition between secondary dialkylammonium ions and dibenzo[24]crown-8 (DB24C8). Naphthalene-containing dialkylammonium threads were tethered to the MCM-41, followed by loading with coumarin 460 and capping with DB24C8. Controlled re...

Present work describes the synthesis of coumarin Mannich bases 4-7 by the application of Mannich reaction on 7-hydroxy-4-methyl coumarin 3 using conventional as well as microwave technology to compare the feasibility, reaction time and yield of the product. For this, 7-hydroxy-4-methyl coumarin 3 was prepared using Pechmann condensation reaction and Mannich bases (4-7) were synthesized by the r...

The biologically relevant arenes ethyl salicylate and salicylic amide as well the fluorescent coumarin pyrene units were functionalized with a cyclopentadiene unit. Re 99mTc complexes of latter two synthesized fully characterized. During crystallization ligands, [2+2] [6+6] cycloadditions observed for modified coumarin. A light-induced mechanism, supported by DFT calculations, is proposed these...

Considering multiple reports on cytotoxic activity of the Artemisia genus and its phytochemicals, in the current study A. armeniaca Lam. and the three components isolated from the plant were subjected to cytotoxic studies. Analytical fractionation of A. armeniaca aerial parts for the first time was directed to the isolation of 7-hydroxy-8-(4-hydroxy-3-methylbutoxy) comarin (armenin), 8-hydroxy-...