Microalgae biomass has garnered significant attention as a renewable energy feedstock and alternative to petroleumbased fuels. The diverse metabolism of green microalgae species additionally provides opportunities for recovery of products for feed, food, nutraceutical, cosmetic, and biopharmaceutical industries. Recently, the concept of using microalgae as part of a biorefinery model has been a...

Computational rational drug design is the application of computer simulation techniques to improve screening processes for new drugs or to design them de novo. The goal is to identify molecules that have high affinity and specificity for a target molecule. Optimizing the electrostatic binding free energy is tractable under certain assumptions as a quadratic optimization problem, but computation...

Although nonnative protein conformations, including intermediates along the folding pathway and kinetically trapped misfolded species that disfavor the native state, are rarely isolated in the solution phase, they are often stable in the gas phase, where macromolecular ions from electrospray ionization can exist in varying charge states. Differences in the structures of nonnative conformations ...

Emerging areas of nanotechnology hold the promise of overcoming the limitations of existing technology for intracellular manipulation. These new developments include the creation of nanocomposites that can be introduced into the cells, targeted to specific subcellular sites, and subsequently used as platforms for initiation of intracellular processes dependent on or aided by locally high concen...

This review focusses on the supramolecular interactions between metal–organic frameworks (MOFs) and included biomolecules. Examples demonstrating utility of crystallography, spectroscopic techniques, computational modelling for probing such are highlighted. Key papers illustrating importance intraframework to structure, flexibility, availability functional groups in bioMOFs also discussed. Fina...