This review focuses on the synthesis of hydrogel networks using thiomers such as thiolated hyaluronic acid, chitosan, cyclodextrin, poly(ethylene glycol) and dextran that are cross-linked via their thiol substructures. Thiomers have been widely investigated matrix hydrogels due to high reactivity these sulfhydryl moieties. They well known for in situ gelling properties formation inter- intra-ch...