نتایج جستجو برای: biomarkers of cardiovascular

تعداد نتایج: 21202018  

2013
J. W. Wang C. M. Gijsberts A. Seneviratna V. C. de Hoog J. E. P. Vrijenhoek A. H. Schoneveld M. Y. Chan C. S. P. Lam A. M. Richards C. N. Lee A. Mosterd S. K. Sze L. Timmers S. K. Lim G. Pasterkamp D. P. V. de Kleijn

Cardiovascular disease is a major public health problem worldwide. Its growing burden is particularly ominous in Asia, due to increasing rates of major risk factors such as diabetes, obesity and smoking. There is an urgent need for early identification and treatment of individuals at risk of adverse cardiovascular events. Plasma extracellular vesicle proteins are novel biomarkers that have been...

Journal: :Circulation. Cardiovascular genetics 2015
Svati H Shah Christopher B Newgard

The genetic architecture underlying the heritability of cardiovascular disease is incompletely understood. Metabolomics is an emerging technology platform that has shown early success in identifying biomarkers and mechanisms of common chronic diseases. Integration of metabolomics, genetics, and other omics platforms in a systems biology approach holds potential for elucidating novel genetic mar...

Journal: :Circulation research 2011
Robert E Gerszten Aarti Asnani Steven A Carr

Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate ...

2009
Johan Sundström

The identification of those persons in the population who have the highest risk of future cardiovascular events is important for targeting intensive preventive efforts. This can be reliably done using a handful of long since established risk factors. The unmet need for new molecular biomarkers for prediction of cardiovascular events in the general population is therefore low. In order for a new...

2015
Carolina Nunes França Maria Cristina de Oliveira Izar Jônatas Bussador do Amaral Daniela Melo Tegani Francisco Antonio Helfenstein Fonseca

Primary prevention of cardiovascular disease is a choice of great relevance because of its impact on health. Some biomarkers, such as microparticles derived from different cell populations, have been considered useful in the assessment of cardiovascular disease. Microparticles are released by the membrane structures of different cell types upon activation or apoptosis, and are present in the pl...

2015
Wang Zhao Shui-Ping Zhao Yu-Hong Zhao

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of v...

2014
Dana Pop Alexandra Dădârlat D Zdrenghea

The incidence of coronary heart disease in premenopausal women is lower than in men because of their hormonal protection. Angina pectoris occurs in women about 10 years later than in men. However, mortality from ischaemic heart disease remains higher in women than in men. Current studies are focusing on novel cardiovascular risk biomarkers because it seems that traditional cardiovascular risk f...

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