نتایج جستجو برای: biological sample

تعداد نتایج: 851239  

Journal: :Clinical trials 2012
Tze Leung Lai Philip W Lavori Mei-Chiung I Shih Branimir I Sikic

BACKGROUND Advances in molecular therapeutics in the past decade have opened up new possibilities for treating cancer patients with personalized therapies, using biomarkers to determine which treatments are most likely to benefit them, but there are difficulties and unresolved issues in the development and validation of biomarker-based personalized therapies. We develop a new clinical trial des...

Journal: :American journal of epidemiology 2013
S Escolano C Hill P Tubert-Bitter

In this paper, we propose new methods for analyzing cases of vaccine adverse events spontaneously reported to a surveillance database. The methods use the self-controlled case series approach, extended in several ways with parametric and nonparametric assumptions to account for the specific features of the data (large amount of underreporting and variation of reporting with time since vaccinati...

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