The European Food Safety Authority (EFSA) is the keystone of European Union (EU) risk assessment for food and feed safety. In collaboration with national authorities and in consultation with its stakeholders, EFSA provides independent scientific advice and information about existing and emerging risks. Assessing biological risks at the human-animal interface is becoming ever more challenging be...

1.1 Using molecular biological methods to identified Salmonella spp. As the industrialization had made food supply to exceed demand, more and more consumers were interested in ‘Delicious food’ than ‘Good quality food’ today and they ask for not only taste but also safety. Microbiological safety is one of the most critical factors for ensuring safe food supply. Fig 1. is a flow chart of traditio...

Background Biotherapy is becoming increasingly important in the treatment of adult-onset Still's disease (AOSD). The aim of our study was to evaluate the efficacy and safety of biological therapy for AOSD resistant to traditional therapy. Patients and methods Database of Library of Congress, the PubMed, and Web of Science Core Collection were used to retrieve relevant articles published in En...

Safety cases offer a means for communicating information about the system safety among the system stakeholders. Recently, the requirement for a safety case has been considered by regulators for safety-critical systems. Adopting safety cases is necessarily dependent on the value added for regulatory authorities. In this work, we outline a structured approach for assessing the level of sufficienc...

It is of crucial importance to evaluate the safety profile of the ingredients used in dermatological emulsions. A suitable equilibrium between safety and efficacy is a pivotal concern before the marketing of a dermatological product. The aim was to assess the safety and biological effects of a new cold processed silicone-based emulsion (SilEmulsion). The hazard, exposure, and dose-response asse...

In many cases, crashes at intersections account for over 50% of all urban road accidents. The need to reduce these crashes has fostered considerable research on the development and evaluation of traffic safety at intersections. This paper introduces a micro-level behavioral method for estimating crash potential at signalized and unsignalized intersections for different traffic characteristics. ...

Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application. Preclinical and clinical studies showed that the main adverse events were allergic reaction and pain at the administration site. To decrease the toxicity, we prepared melittin nano-liposomes by encapsulating melittin with poloxamer...

System safety research has a weakness in terms of evaluation. In particular, the field has a poor track record for applying appropriate research methods to the questions we wish to answer, and for evaluating the answers in a convincing way. Given changes in government and public attitudes to research funding, this will be an increasing concern in the near future. In this paper, we define a taxo...

Biological agents targeting a specific molecule have extraordinarily fine specificity and powerful functional capabilities. By the introduction of biological therapy, management of rheumatoid arthritis has undergone a revolution and a paradigm shift. In this review, I will summarize the role in the pathogenesis of rheumatoid arthritis of the molecules targeted by biologi...