Treatment planning for ion therapy requires precise knowledge about the biological effectiveness of particle beams, which is strongly determined by the microscopic radial energy deposition around individual ion tracks. Therefore, we applied the Local Effect Model (LEM) to investigate the dependence of the relative biological effectiveness (RBE) on different representations of the radial dose di...

We show that the complex automata (CxA) paradigm can serve as a robust general framework which can be applied for developing advanced models of biological systems. CxA integrates particle method (PM) and cellular automata (CA) computational techniques. Instead of developing complicated multi-scale models which consist of many submodels representing various scales coupled by a scales-bridging me...

Particle-based reaction-diffusion algorithms facilitate the modeling of the diffusional motion of individual molecules and the reactions between them in cellular environments. A physically realistic model, depending on the system at hand and the questions asked, would require different levels of modeling detail such as particle diffusion, geometrical confinement, particle volume exclusion or pa...

A variety of alpha (α)-particle emitters are found ubiquitously in the environment, in commercial/therapeutic prod-ucts and are a potential threat in the form of a radiological dispersal device. Our understanding of the biological mechanisms and long-term health effects resulting from α-particle exposure is limited. Exposure to radiation induces modulations of gene networks, possibly through mi...

Biological sounds produced on coral reefs may provide settlement cues to marine larvae. Sound fields are composed of pressure and particle motion, which is the back and forth movement of acoustic particles. Particle motion (i.e., not pressure) is the relevant acoustic stimulus for many, if not most, marine animals. However, there have been no field measurements of reef particle motion. To addre...

The effect of geometry and material of the Micro/Nano particle on contact mechanic for manipulation was studied in this work based on atomic force microscopy. Hertz contact model simulation for EpH biological micro particle with spherical, cylindrical, and circular crowned roller shape was used to investigate the effect of geometry on contact simulation process in manipulation. Then, to val...

Obejective(s): In this research, magnetite nanoparticles with an average size of 23-36 nm were successfully synthesized via surfactant-free electrochemical method using iron as the anode and water as the electrolyte in a closed aqueous system in the presence of NaOH at room temperature. Methods: The effect of the current density on product formation...

Nowadays nanotechnology as a new direction of science allows us to develop therapeutic methods of the endogenous intoxication syndrome and to create a new class of biocompatible sorbents. In Ukraine first preparations of medical nanotechnology were produced and patented in 1998. These are IKBB (intracorporeal biocorrector), magnet-controlled sorbent (MCS-B), and Micromage-B. The preparations ar...

A major hurdle in the development of biomedical nanoparticles (NP) is understanding how they interact with complex biological systems and navigate biological barriers to arrive at pathological targets. It is becoming increasingly evident that merely controlling particle physicochemical properties may not be sufficient to mediate particle biodistribution in dynamic environments. Thus, researcher...

Coupled biological-physical models have been used to enhance understanding of fisheries recruitment, identify marine protected areas, and, in this case, determine the potential to establish or restore a self-sustaining population of oysters. The overall objective of our research program is to determine the potential distance and rate of larvae dispersal for two oyster species, Crassostrea virgi...