The facility and versatility of microRNAs (miRNAs) to evolve and change likely underlies how they have become dominant constituents of eukaryotic genomes. In this opinion article I propose that trans-acting small interfering RNA gene 4 (TAS4) evolution may be important for biosynthesis of polyphenolics, arbuscular symbiosis, and bacterial pathogen etiologies. Expression-based and phylogenetic e...

The effect of quercetin, a plant-derived bioflavonoid with documented positive effect on the cardiovascular system, was examined after 4-week supplementation in the dose of 20 mg kg(-1) x day(-1) to young male normotensive control (C) and to spontaneously hypertensive rats (SHR) over the period of their 5(th)-8(th) week of age. The study was focused on the influence of quercetin on properties o...

Luteolin and delphinidin are the flavonoids with known protective roles. They inhibit genotoxic effects induced by halogenated boroxine (HB) in vitro. Statistically significant decrease frequency of micronuclei nuclear buds suppression occurrence aberrant cells were observed before, but mechanism its anti-genotoxic activity is still not clear. In our experiment we aimed to quantify HB on relati...

One of the most important mechanism by which bioflavonoids can exert their effects in cancer treatment, is through interaction with bio-macromolecules such as DNA. Recent literature emphasizes role Bavachinin (BVC) an emerging anticancer agent. However, there are no reports on its ability to interact The present study investigated DNA binding properties BVC many spectroscopic and computational ...

INTRODUCTION Cypermethrin causes its neurotoxic effect through voltage-dependent sodium channels and integral protein ATPases in the neuronal membrane. Brain and nerve damage are often associated with low residual level of pesticides. In vitro and in vivo studies have also shown that pesticides cause free radical-mediated tissue damage in brain. Propolis has antioxidant properties. The main che...

Flavangenol, one of extract of French maritime pine bark, is a complex mixture of bioflavonoids with oligometric proanthocyanidins as the major constituents. These constituents, catechin and procyanidin B(1), are water-soluble derivatives of flavangenol. In this study, we investigated the antioxidant effects of flavangenol on reactive oxygen species such as hydroxyl radical, superoxide anion an...

Hemorrhoids and varicose veins are common conditions seen by general practitioners. Both conditions have several treatment modalities for the physician to choose from. Varicose veins are treated with mechanical compression stockings. There are several over-the-counter topical agents available for hemorrhoids. Conservative therapies for both conditions include diet, lifestyle changes, and hydrot...

(PBE), is a complex mixture of bioflavonoids with oligomeric proanthocyanidin as main constituents. The nutritional supplementation of PBE produces a variety of potentially protective effects against chronic age-related diseases such as atherosclerosis, hypertension, and diabetes. It has recently been reported that many beneficial effects of PBE are closely related to its potent antioxidative a...