During mitosis chromosomes use a complex network of dynamic microtubules to find the cell equator in preparation for division signals. The roles of cellular chemical signals in mechanisms driving mitotic chromosomal movements are not well understood. In this paper we propose a mathematical model of this process which incorporates a molecular scale model of kinetochore-microtubule interactions i...

Low temperature is one of the serious environmental stresses affecting plant growth and agricultural production. It not only inhibits metabolic reactions but also causes osmotic, oxidative, and other damages [1]. Chilling temperatures that range from 0 to 12°C are common during the growing season and can substantially decrease plant productivity [2]. Plants respond and acclimate to chilling str...

Bacteria resembling two Bordetella species were isolated from both normal and pneumonic ovine lungs using a selective charcoal agar. Twenty-eight of the 33 isolates showed similarities to stock NCTC B. parapertussis strains in their SDS-PAGE gel protein profiles, in their biochemical reactions and in causing browning on tyrosine agar. Five isolates behaved similarly to stock B. bronchiseptica s...

Biochemical reactions in crowded fluids have been predicted to differ strongly from those in aqueous solutions. Both excludedvolume interactions with surrounding macromolecules and crowding-induced subdiffusion have been predicted to stabilize complex formation of reaction partners. Here we show that both facets of crowding strongly alter the stochastic opening and closing of a single-stranded ...

The advent of room-temperature single-molecule imaging and spectroscopy in the early 1990s made it possible to follow biochemical reactions and conformational dynamics of an individual enzyme molecule in real time, yielding new information about the working of enzymes in vitro. This eventually led to the recent success of probing single-molecule biochemical reactions in a living cell with high ...

We use the Litvinov-Maslov correspondence principle to reduce and hybridize networks of biochemical reactions. We apply this method to a cell cycle oscillator model. The reduced and hybridized model can be used as a hybrid model for the cell cycle. We also propose a practical recipe for detecting quasi-equilibrium QE reactions and quasi-steady state QSS species in biochemical models with ration...

Recent advances in biochemical computing, i.e., information processing with cascades of primarily enzymatic reactions realizing computing gates, such as AND, OR, etc., as well as progress in networking these gates and coupling of the resulting systems to smart/responsive electrodes for output readout, have opened new biosensing opportunities. Here we survey existing enabling research results, a...

The ability to trace the fate of individual atoms through the metabolic pathways is needed in many applications of systems biology and drug discovery. However, this information is not immediately available from the most common metabolome studies and needs to be separately acquired. Automatic discovery of correspondence of atoms in biochemical reactions is called the "atom mapping problem." We s...

Although the organisms now known as Listerella were first reported as a new species by Murray, Webb and Schwann (1926), and were given the genus name by Pirie (1927), earlier reports contain descriptions which indicate that the organisms were seen prior to 1926. Atkinson (1917) noted a gram-positive diphtheroid organism in five human cases of what was thought to be epidemic cerebrospinal mening...

Providencia rettgeri (P. rettgeri) is the key organism for gastrointestinal tract infections due to its high virulence properties. The current study was designed to investigate the effect of Mr. Trivedi’s biofield energy treatment on P. rettgeri in lyophilized as well as revived state for antimicrobial susceptibility pattern, biochemical characteristics, and biotype number. The lyophilized stra...