Autism is a developmental disorder characterized by disturbance in language, perception and socialization. A variety of biochemical, anatomical and neuroradiographical studies imply a disturbance of brain energy metabolism in autistic patients. The underlying aetiology of the disturbed bioenergetics metabolism in autism is still unknown. The autism (sometimes called “classical autism”) is the m...

Late long-term potentiation (L-LTP) denotes long-lasting strengthening of synapses between neurons. L-LTP appears essential for the formation of long-term memory, with memories at least partly encoded by patterns of strengthened synapses. How memories are preserved for months or years, despite molecular turnover, is not well understood. Ongoing recurrent neuronal activity, during memory recall ...

The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders, including Parkinson's disease (PD), Attention Deficit Hyperactivity Disorder (ADHD), Tourette's syndrome, and dystonia. Most of current basal ganglia research?in both animals and humans?attempts to understand the neural and biochemical substrates of ...

Background: A high percentage of the patients referred to dermatologic clinics are either suffer from self inflicted disorders or from misinterpretation about their own health and organ integrity and or may suffer from different skin sensations including itching, pain, and burning; all of which may develop as a result of their underlying psychopathologies. Objective: Identification of underlyin...

Protein amyloid aggregation has been associated with more than 50 human disorders, including the most common neurodegenerative disorders Alzheimer’s and Parkinson’s disease. Interfering this process is considered as a promising therapeutic strategy for these diseases. Our understanding of its role in disease typically limited by use ensemble-based biochemical biophysical techniques, owing to in...

Magnesium, the fourth most abundant cation in human body, is involved several essential physiological, biochemical, and cellular processes regulating cardiovascular function. Mammalian cells regulate Mg2+ concentration through specialized influx efflux transport systems that have only recently been characterized. controlled by cloned transporters including Mrs2p, SLC41A1, ACDP2, MagT1, TRPM6 TR...

tears have antimicrobial, nourishing, mechanical, and optical properties and contain components such as growth factors, fibronectin and vitamins to support proliferation, migration and differentiation of corneal and conjunctival epithelial cells. lack of these epitheliotrophic factors, as in dry eye, can result in severe ocular surface disorders such as persistent epithelial defects. recently, ...

objective: the protective effect of silymarin (smn) on mycophenolate mofetil (mmf)–induced duodenal disorders was investigated. materials and methods: forty-two wistar rats were assigned to seven groups including control and test groups. the control animals received saline and the test animals were treated with mmf (30 mg/kg, orally) and saline, mmf and smn (25, 50, and 100 mg/kg, orally), mmf ...

Background. The spread of post-traumatic stress disorder (PTSD) and overcoming its consequences, including immune-related disorders, is one the critical issues requiring extensive study resolution in practical medicine, particularly under present conditions Ukraine.
 Materials methods. group consisted 79 (27.5%) patients with verified PTSD: 46 (58.2%) female 33 (41.8%) male, an average age...

OBJECTIVE To evaluate the efficacy and relative costs of different screening methods for the identification of alcohol use disorders in an opportunistic screening programme in primary care in the United Kingdom. DESIGN Comparative study. SETTING Six general practices in south Wales. PARTICIPANTS 194 male primary care attendees aged 18 or over who completed an alcohol use disorders identif...