Adhesion is a way of life in echinoderms. Indeed, all the species belonging to this phylum use adhesive secretions extensively for various vital functions. According to the species or to the developmental stage considered, different adhesive systems may be recognized. (1) The tube feet or podia are organs involved in attachment to the substratum, locomotion, feeding or burrowing. Their temporar...

The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natur...

Photodynamic inactivation (PDI) combined with chitosan has been shown as a promising antimicrobial approach. The purpose of this study was to develop a chitosan hydrogel containing hydroxypropyl methylcellulose (HPMC), chitosan and toluidine blue O (TBO) to improve the bactericidal efficacy for topical application in clinics. The PDI efficacy of hydrogel was examined in vitro against the biofil...

Time-varying interactions of human fetal osteoblastic cells (hFOB 1.19) with materials of diverse chemical composition and surface energy, including biodegradable lactide/glycolide-based polymers, were assessed using a combination of assays sensitive to different phases of cell-substratum compatibility. Short-term (minutes to hours) cell-attachment-rate assays were used to measure the earliest ...

This work explores how long-range non-specific interactions, resulting from small amounts of adsorbed fibrinogen, potentially influence bioadhesion. Such non-specific interactions between protein adsorbed on a biomaterial and approaching cells or bacteria may complement or even dominate ligand-receptor mating. This work considers situations where the biomaterial surface and the approaching mode...

Buccal films were prepared from aqueous and ethanolic Metolose gels using the solvent casting approach (40°C). The hydration (PBS and simulated saliva), mucoadhesion, physical stability (20°C, 40°C), in vitro drug (omeprazole) dissolution (PBS and simulated saliva), ex vivo permeation (pig buccal mucosa) in the presence of simulated saliva, ex vivo bioadhesion and cell viability using MTT of fi...

BACKGROUND Peroral β-galactosidase preparations for the management of lactose intolerance need to be administered in large doses (1500 to 6000 U) immediately before or together with a lactose-containing meal. AIM Therefore, this work aimed at developing an innovative long-acting formulation. For this purpose, biodegradable polymeric microcarriers were functionalized with β-galactosidase and t...

using controlled drug delivery devices is one of the novel methods of drug delivery which is used to perform drug therapy with the minimum side effects. mucoadhesive polymers are one of these devices. chitosan is a natural polymer which is a suitable candidate for this purpose due to it is biocompatibility, bioadhesion and high capability to adsorb peptide drugs. since gi tract has both acidic ...

ORIGINAL RESEARCH ARTICLE ABSTRACT Background: Carbamazepine (CBZ) is an antiepileptic orally administered drug, but due to its low solubility in water, its gastrointestinal absorption is slow and irregular, leading to delay brain uptake with consequent peripheral side actions. The main objective of this study was to assess mucoadhesive CBZ-loaded o/w nanoemulgel (MNEG) as a nasal delivery syst...

An endeavor has been made to create buccoadhesive bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer to release the drug for extended period of time with reduction in dosing recurrence. Tablets of Tizanidine hydrochloride were prepared by direct compression method using bioadhesive polymer tamarind seed gum with backing layer of ethyl cellulose. The ph...