The objective of this work is to develop bioactive glass coatings for metallic orthopedic implants. A new family of glasses in the SiO2–Na2O–K2O–CaO–MgO–P2O5 system has been synthesized and characterized. The glass properties (thermal expansion, softening and transformation temperatures, density and hardness) are in line with the predictions of established empirical models. The optimized firing...

INTRODUCTION: Osteoporotic patients, smokers and diabetics are among those who represent higher risks with regard to bone formation. In these clinical situations where bone regeneration can be especially difficult there is a need for an active agent or material which can stimulate osteoblasts in addition to providing a scaffold for growth. Extensive research has been performed on silicon and ca...

The cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. This study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder and micropowder. Human HGF1-PI53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ mL concentrations of the two bioacti...

The present study investigates a new family of bioactive glass nanoparticles with and without Sr-doping focusing on the influence of the nanoparticles on human bone marrow stromal cells (hBMSCs) in vitro. The bioactive glass nanoparticles were fabricated by flame spray synthesis and a particle diameter of 30–35 nm was achieved. Glass nanoparticles were undoped (BG 13-93-0Sr) or doped with 5 wt%...

Oxynitride glasses are found as grain boundary phases in silicon nitride ceramics. They are effectively alumino-silicate glasses in which nitrogen substitutes for oxygen in the glass network, and this causes increases in glass transition and softening temperatures, viscosities (by two to three orders of magnitude), elastic moduli and microhardness. Calcium silicate-based glasses containing fluo...

objective: bioactive glass 45s5 is a surface reactive glass-ceramic biomaterial, developed in 1969. bag 45s5 with particle size of 20-60 nm has the ability of bone regeneration, broad spectrum antibacterial effect, repairs and replaces diseased or damaged bone. the aim of this study was to evaluate the antibacterial activity and determine mic and mbc values of nano-bag45s5 on streptococcus muta...

The development of bioactive glass-ceramic materials has been a topic of great interest aiming at enhancing the mechanical strength of traditional bioactive scaffolds. In the present study, we test and demonstrate the use of Biosilicate® glass-ceramic powder to fabricate bone scaffolds by the foam replica method. Scaffolds possessing the main requirements for use in bone tissue engineering (95%...

This research has been done to study characteristic and biocompatible evaluation of a nano-biocompositeceramic with the bioglass (BG) as a first phase. In this regard, synthesis of S53P4 (53% SiO2, 4% P2O5,23% Na2O and 20% CaO) bioglass has been considered as the first phase and flourapatite (FA) consideredas the second phase. Afterwards, nanocomposite with the base of S53P4 b...

In this work we synthesized mesoporous bioactive glass nanospheres (nMBG) with the aim to utilize them as substrates for loading one of the most potent amino-bisphosphonates, alendronate (AL). The results of the chemical and structural characterization show that the nMBG display a relatively high surface area (528 m²/g) and a mean pore volume of 0.63 cm³/g, both of which decrease on increasing ...