In a recent paper, Bardsley & McGinlay (1987) use saturation functions for binding of a ligand to a protein with an unknown number of binding sites to explore the power and reliability of the F test when used outside its range of strict validity. In the course of their discussion they make the interesting and novel observation that binding equations do not form a nested set: increasing the numb...

The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers variable lengths is described. multivalent inhibition potencies for were investigated acetylcholinesterase. Two displayed small but significant potency in which affinity each increased up 3.2 times when they connected scaffold.

The binding of human immunodeficiency virus type 1 (HIV-1) to the cellular receptor CD4 has been suggested to induce conformational changes in the viral envelope glycoproteins that promote virus entry. Conserved, discontinuous epitopes on the HIV-1 gp120 glycoprotein recognized by the 17b, 48d, and A32 antibodies are preferentially exposed upon the binding of soluble CD4 (sCD4). The binding of ...

To develop a general approach to designing cofactor-binding sites for catalytic antibodies, we characterized structural patterns in the binding sites of antibodies and zinc enzymes. Superposition of eight sets of antibody light- and heavy-chain variable domains identified structurally conserved sites within the sequence-variable complementarity determining regions. The pattern for catalytic zin...

Metal ions in protein are critical to the function, structure and stability of protein. For this reason accurate prediction of metal binding sites in protein is very important. Here, we present our study which is performed for predicting metal binding sites for histidines (HIS) and cysteines from protein sequence. Three different methods are applied for this task: Support Vector Machine (SVM), ...

results in this study, 45 (13.4 %) urine samples were positive for candida species (17 males and 28 females). the most common isolated yeast was candida albicans (34%), followed by c. glabrata (32.1%), c. tropicalis (9.4%), other candida species (22.6%), and rhodotorula species (1.9%). the mean serum levels of mbl were 0.85 ± 0.01 ng/ml and 1.02 ± 0.03 ng/ml among candiduric patients and contro...

For connectionistnetworks to be adequate for higher level cognitive activities such as natural language interpretation, they have to generalize in a way that is appropriate given the regularities of the domain. Fodor and Pylyshyn (1988) identified an important pattern of regularities in such domains, which they called systematicity. Several attempts have been made to show that connectionist net...