background: this study was performed to find out whether transcutaneous bilirubinometry could be a valid screening method for hyperbilirubinemia in preterm infants, especially for those who needed mechanical ventilation. methods: we evaluated 63 preterm iranian newborns who were managed in the neonatal intensive care unit of shahidbeheshti university hospital, isfahan, iran from april 2009 to a...

background and aim: neonatal jaundice is one of the common causes of early sensori­neural hearing loss and an important cause of deafness in children. auditory responses are the most sensitive parts of the nervous system to the toxic effect of bilirubin. this study was aimed to examine the effect of neonatal hyperbili­rubinemia and its treatment on auditory brain­stem responses (abr). methods: ...

I studied the effects of serum dilution and oxidation of albumin-bound bilirubin on the accuracy of results by the peroxidase method for assessing bilirubin-albumin binding. The apparent concentration of unbound bilirubin decreases with dilution of bilirubin-enriched serum or defatted-albumin solutions, the effect being more marked with serum. The decrease in apparent unbound bilirubin does not...

Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic cell transplantation. We analyzed the kinetics of bilirubin and liver enzymes in 47 cases with liver GVHD and in 47 cases without GVHD after allogeneic transplantation for various hematological malignancies. The duration of an liver GVHD episode (LGVHD) was defined as the interval from the point wh...

BACKGROUND Bilirubin has been seen as a toxic waste product since it is product of heme metabolism. It's the latest in a series of studies showed that the concentration of serum bilirubin is associated with various diseases such as multiple sclerosis, hypertension and cardiovascular diseases (CVD). However, no study to investigate the association between serum bilirubin and migraine, thus, our ...

BACKGROUND Unconjugated hyperbilirubinemia may cause brain damage in infants, and globally remains a source of neonatal morbidity and mortality. A significant inter-individual variability in vulnerability to bilirubin toxicity remains largely unexplained. An enzyme located in mitochondria oxidizes bilirubin. We hypothesized that inhibiting bilirubin oxidation in human neuronal cell cultures exp...

Inhibition of UDP-glucuronosyltransferase (UGT) 1A1-catalyzed bilirubin glucuronidation by drug compounds may potentially be of clinical concern. However, in drug discovery and development settings, bilirubin is less than an ideal in vitro probe for assessing the potential of a chemical entity to inhibit bilirubin glucuronidation. In part, this is due to the propensity of bilirubin to photodegr...

Biliverdin reductase (BVR: bilirubin:NAD(P)+ oxidoreductase; EC 1.3.1.24) is responsible for the conversion of biliverdin to bilirubin a t the end of the haem catabolic pathway. Elevated levels of serum bilirubin (hyperbilirubinaemia) occur when bilirubin conjugation is impaired. When the bilirubin carrying capacity of the blood (mediated by serum albumin) is exceeded, the pigment becomes depos...

background: considering the increasing rates of early hospital discharge and kernicterus in healthy full term newborns, timely identification of neonates at risk of severe hyperbilirubinemia is of great significance. the aim of this study was to investigate the predictive value of umbilical cord serum (ucs) bilirubin level for subsequent hyperbilirubinemia. moreover, we compared the predictive ...

Gunn rats, which have defects in bilirubin and 4-nitrophenol UDP-glucuronyltransferases (GT), were crossed with LA Wistar rats with a defect in androsterone GT. The F1 hybrids showed normal GT activities towards androsterone, bilirubin and 4-nitrophenol, demonstrating that Gunn and LA ('low activity') Wistar rats inherit a homozygous dominant trait for androsterone GT and bilirubin GT respectiv...