New highly sensitive voltammetric DNA-sensors have been developed for the detection of cytostatic drug doxorubicin based on Azure A electropolymerized various carbon nanomaterials, i.e., functionalized multi-walled nanotubes (fMWCNTs) and black (CB). Carbon materials promote electropolymerization dye applied as a matrix DNA molecules saturated with methylene blue (MB) molecules. Interaction int...

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Mechanochemical synthesis of bifunctional Co–N–C electrocatalysts.

A new folate-conjugated gold nanoparticle (AuNP) has been designed to selectively target the folate receptor that is overexpressed on the surface of tumoral cells. For this purpose, we made 4-aminothiophenol, as a bifunctional linker to react with HAuCl4 in the presence of sodium borohydride and it was binded to the AuNP surface through its thiol group. Then, we conjugated amino-terminated nano...

Bifunctional Catalysts In article number 2201974, Yunqi Liu, Xuan Yang, Xiang Feng, Yuan Pan, and co-workers propose an encapsulation-adsorption-pyrolysis strategy for constructing Co-Te diatomic sites with special CoN3C1-TeN1C3 coordination structure anchored in N-doped carbon, as efficient bifunctional catalysts synergistic electrocatalytic hydrogen evolution oxygen reduction. This work provi...

N-acetylglutamate synthase (NAGS) catalyzes the production of N-acetylglutamate (NAG) from acetyl-CoA and L-glutamate. In microorganisms and plants, the enzyme functions in the arginine biosynthetic pathway, while in mammals, its major role is to produce the essential co-factor of carbamoyl phosphate synthetase 1 (CPS1) in the urea cycle. Recent work has shown that several different genes encod...

Thymidylate synthetase and dihydrofolate reductase exist as a bifunctional protein in a number of species of protozoa which span diverse groups of the subkingdom. The enzymes copurify upon gel filtration and on affinity chromatography columns specific for dihydrofolate reductase. The bifunctional protein has been found in species of Crithidia, Leishmania, Trypanosoma, Plasmodium, Eimeria, Tetra...