Distal forearm fractures are among the most common injuries presenting to the Pediatric Emergency Department (PED). Bier block (BB), or intravenous regional anesthesia, is a safe and effective alternative to procedural sedation for closed reduction of forearm fractures, and is associated with fewer adverse events, a shorter length of stay and reduced costs. BB has long remained relatively under...

Complex regional pain syndrome (CRPS) type I is a painful and disabling syndrome that is accompanied by physical changes in the affected extremity. It generally occurs after trauma, manifesting as pain that is out of proportion to the inciting event. Treatment of the disorder is difficult, with many patients being refractory to multiple pharmacologic regimens. Regional anesthetic techniques, in...

Spinal anaesthesia developed in the late 1800s with the work of Wynter, Quincke and Corning. However, it was the German surgeon, Karl August Bier in 1898, who probably gave the first spinal anaesthetic. Bier also gained first-hand experience of the disabling headache related to dural puncture. He correctly surmised that the headache was related to excessive loss of cerebrospinal fluid (CSF). In...

Vein differentiation is controlled by groups of genes that act in two developmentally distinct phases. During mid-third larval instar and early prepupal stages, the positions of vein territories are defined within the monolayer of wing imaginal disc cells (reviewed by Bier, 2000). In the second phase of vein development, during pupal stages, the vein versus intervein cell fate choice is resolve...

The principal investigators would like to thank their collaborators, research assistants and master students which were incorporated in the research project and essentially contribute to the planned assignments. These are the PhD students Wolfgang Bier (UniK), Ulrich Heisserer (TUM), and Magda Martins-Wagner (UniBW München) as well as the students Idit Cohen, Shachar Koen, and Alexander Ripp. F...

In 1992, Thomas Bier introduced a surprisingly simply way to construct a large number of simplicial spheres. He proved that, for any simplicial complex ∆ on the vertex set V with ∆ 6= 2 , the deleted join of ∆ with its Alexander dual ∆∨ is a combinatorial sphere. In this paper, we extend Bier’s construction to multicomplexes, and study their combinatorial and algebraic properties. We show that ...