نتایج جستجو برای: beta cell
تعداد نتایج: 1813081 فیلتر نتایج به سال:
Islets are composed mostly of beta-cells, and therefore stem cell research has concentrated on generating purified beta-cells, neglecting the other endocrine cell types in the islet. We investigated the presence of endocrine non-beta-cells after islet transplantation. In addition, we studied whether the transplantation of pure beta-cells, in volumes similar to that used in islet transplantation...
Although immune interventions have shown great promise in type 1 diabetes mellitus (T1D) clinical trials, none are yet routine use or able to achieve insulin independence patients. In addition this, the principles of T1D treatment remain essentially unchanged since isolation insulin, almost a century ago. is characterized by deficiency as result destruction insulin-producing beta cells mediated...
Introduction: G-proteins have an important role in the cell signaling of numerous receptors. The situation of G-proteins in health and disease and their critical role in the development of diabetic side effects is an interested scientific field. Here, the changes in the expression of G-protein subunits (Gαi, Gαs and Gβ) were evaluated in hyperglycemic situation of PC12 cells as...
Abstract Purpose of Review Beta cell replacement therapy as a form islet transplantation is promising alternative with the possibility to make selected patients type 1 diabetes (T1D) insulin independent. However, this technique faces challenges such extensive activation host immune system post-transplantation, lifelong need for immunosuppression, and scarcity donor pancreas. Advancement in tiss...
background: adipose-derived stem cells (adscs) are a population of pluripotent cells used for tissue engineering purposes. the main purpose of the present study was to transdifferentiate the adscs to schwann-like cells and to determine the intensity of apoptosis in adscs during the transdifferentiation process. methods: adscs were isolated from the inguinal adipose tissue of adult rats and th...
OBJECTIVE Generating functional beta-cells by inducing their proliferation may provide new perspectives for cell therapy in diabetes. Transcription factor E2F1 controls G(1)- to S-phase transition during the cycling of many cell types and is required for pancreatic beta-cell growth and function. However, the consequences of overexpression of E2F1 in beta-cells are unknown. RESEARCH DESIGN AND...
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