Mycobacterium tuberculosis (Mtb) maintains its intrabacterial pH (pHIB) near neutrality in the acidic environment of phagosomes within activated macrophages. A previously reported genetic screen revealed that Mtb loses this ability when the mycobacterial acid resistance protease (marP) gene is disrupted. In the present study, a high throughput screen (HTS) of compounds against the protease doma...

BACKGROUND Intercropping systems could increase crop diversity and avoid vulnerability to biotic stresses. Most studies have shown that intercropping can provide relief to crops against wind-dispersed pathogens. However, there was limited data on how the practice of intercropping help crops against soil-borne Phytophthora disease. PRINCIPAL FINDINGS Compared to pepper monoculture, a large sca...

A new series of the title compounds incorporated into diverse N and O heterocyclic moieties of pharmacoavailability as anti-inflammatory and analgesic agents, were synthesized starting with 6,8-dibromo-2-phenyl-4H-3,1-benzoxazin-4-one (I) by its fusion with p-aminoacetophenone to give the new intermediate compound, 6,8-dibromo-2-phenyl-3-(4-acetylphenyl)-4(3H)-quinazolinone (II). The one pot re...

1 2 Scope: Understanding relationships between dietary whole grain and health is hindered by 3 incomplete knowledge of potentially bioactive metabolites derived from these foods. We 4 aimed to discover compounds in urine correlated with changes in amounts of wholegrain rye 5 consumption. 6 Methods and Results: After a wash-out period, volunteers consumed 48 g wholegrain rye 7 foods per day for ...

Phytoalexins are low molecular weight antimicrobial compounds that are synthesized in response to pathogen attack. The phytoalexin camalexin, an indole derivative, is produced by Arabidopsis in response to infection with the bacterial pathogen Pseudomonas syringae. The phytoalexin deficient 3 ( pad3 ) mutation, which causes a defect in camalexin production, has no effect on resistance to P. syr...

Kenkichi Ebisui, Atsushi Ishihara, Nobuhiro Hirai and Hajime Iwamura Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan, and CREST, Japan Science and Technology Corporation (JST) Z. Naturforsch. 53c, 793-798 (1998); received April 14/May 18, 1998 Benzoxazinones, Zea mays, Gramineae, ß-Glucosidase 2,4-Dihydroxy-7-methoxy-l,4-benzoxazin-3-on...

To identify novel genes involved in cannabinoid receptor-mediated signaling, we used cDNA microarrays to detect changes in mRNA expression in the forebrains of mice 12 h after they were given a single intraperitoneal dose of the naturally-occurring Cannabis sativa alkaloid Delta(9)-tetrahydrocannabinol (Delta(9)-THC) or the synthetic cannabinoid receptor agonist (R)-(+)-2,3-dihydro-5-methyl-3-[...

Akira Oikawa, Kenkichi Ebisui, Masayuki Sue, Atsushi Ishihara and Hajime Iwamura Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan, and CREST, Japan Science and Technology Corporation (JST) Z. Naturforsch. 54c, 181-185 (1999); received November 19, 1998/January 11, 1999 Benzoxazinones, Zea mays, Gramineae, ß-Glucosidase Occurrence and pro...

Plants show considerable within-species variation in their resistance to insect herbivores. In the case of Zea mays (cultivated maize), Rhopalosiphum maidis (corn leaf aphids) produce approximately twenty times more progeny on inbred line B73 than on inbred line Mo17. Genetic mapping of this difference in maize aphid resistance identified quantitative trait loci (QTL) on chromosomes 4 and 6, wi...

Plant resistance is a promising control method for the two most damaging insect pests of maize, Zea mays L.: the European corn borer, Ostrinia nubilalis (Hübner), and the western corn rootworm, Diabrotica virgifera virgifera LeConte. Fifteen experimental lines of maize, derived from a backcross breeding program designed to introgress resistance to European corn borer from Peruvian maize into tw...