The immunosuppressive actions of benzo(a)pyrene have been proposed to be mediated by reactive metabolites rather than the parent compound. Reactive metabolites which suppress splenic humoral immune responses are thought to be generated within the spleen rather than in distant tissues. Although the spleen has been shown to be capable of metabolizing benzo(a)pyrcne, the relative amounts and types...

ABSTRACT. The aim of this investigation was to assess the presence 16 PAHs (naphthalene, acenaphthylene, acenaphthene, fluorene, anthracene, phenanthrene fluoranthene, benz[a]anthracene, pyrene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, dibenzo[a,h]anthracene, benzo[ghi]perylene, and indeno[1,2,3-cd]pyrene with symbols Nap, Ace, Ane, Flu, Ant, Phe, Flt, BaA, Pyr, Chr...

The mass, chemical composition and toxicological properties of fine particulates (PM2.5) emitted from cooking activities in three Hong Kong based restaurants two simulated experiments were characterized. Extracts the PM2.5 samples elicited significant biological [cell viability, generation reactive oxygen species (ROS), DNA damage inflammation effect (TNF-α)] a dose-dependent manner. PAHs, oxyg...

BACKGROUND Phenethyl isothiocyanate (PEITC), the most comprehensively studied aromatic isothiocyanate, has been shown to act as an anti-cancer agent mainly through modulation of biotransformation enzymes responsible for metabolizing carcinogens in the human body. Humans are often exposed to carcinogenic factors, some of which through the diet, such as polycyclic aromatic hydrocarbon benzo[a]pyr...

Polycyclic aromatic hydrocarbons (PAHs) and dioxins are lipophilic organic pollutants occurring widely in the terrestrial environment. In order to study the PAHs and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) transfer in the food chain, pigs have been fed with milk mixed either with 14C-phenanthrene, with 14C-benzo[a]pyrene or with 14C-TCDD. The analysis of portal and arterial blood radioactivi...

Benzo[a]pyrene is considered as a priority pollutant because of its carcinogenic, teratogenic and mutagenic effects. The highly recalcitrant nature of Benzo[a]pyrene poses a major problem for its degradation. White-rot fungi such as Pleurotus ostreatus can degrade Benzo[a]pyrene by enzymes like laccase and manganese peroxidase. The present investigation was carried out to determine the extent o...

Within 4 hr after administration of butylated hydroxyanisole (BHA) by p.o. intubation, marked changes in the microsomab metabolism of benzo(a)pyrene (BP) occur. Liver microsomes isolated from female A/HeJ mice under these conditions show a depression of BP metabolism by more than 16%. The effects on individual metabolites as determined by high-pressure liquid chromatography differ. Relative inc...

Benzo(a)pyrene 1,6-, 3,6-, and 6,1 2-quinones were found to be noncompetitive inhibitors of mixed-function oxidation of benzo(a)pyrene (BP) and frans-7,8-dihydro-7,8-dihydroxybenzo(a)pyrene (BP 7,8-dihydrodiol). BP 6,1 2-quinone was the most potent inhibitor of both BP and BP-7,8-dihydrodiol oxi dation followed by BP 1,6-quinone and BP 3,6-quinone. The K, for inhibition of BP mixed-function oxi...

The catalytic activities of hepatic microsomes from untreated, phenobarbital-treated and 3methylcholanthrene-treated adult rabbits with respect to benzo[a]pyrene hydroxylation and the activation of (-)truns-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene[( -)~ans-7,8-diol] to DNA-binding metabolites were determined in the absence and presence of mixed-function oxidase inhibitors and compared to the cor...