A new multidisciplinary synthetic approach comprising polymer-support synthesis, microwave-assisted synthesis, and multicomponent condensation facilitates synthesis of triaza-fluorenes library with a set of advantages such as rapid process, simple purification, and structural diversity in one shot. Microwave-assisted multistep synthetic protocol was used to construct the benzimidazole ring on s...

in an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (pocl3). the synthesized compounds were identified by 1h-nmr, 13c-nmr, ft-ir spectroscopic techniques and elemental analysis. all products were...

Microsomes isolated from HeLa cells during DNA replication synthesize electrophoretically identifiable histones in vitro. Inhibition of DNA synthesis with hydroxyurea or high concentrations of thymidine results, within 30 min, in a termination of histone synthesis in vitro. Under these conditions, the labeling of other acid-soluble, nonhistone proteins is not affected. Inhibition of RNA synthes...

Catalyst-mediated hydrogenation of ketones via hydride transfer can be directly used in the synthesis alcohols which exhibit great potential practical pharmaceuticals. The application Ni-NHC complexes is still limited. In a pursuit to study effect Ni-NHC-based reactivity towards hydrogenation, we have studied catalytic efficiency pendent-type nickel complex [Ni(NHC)2](PF6)2 constructed from ben...