A systematic design of experiments (DOE) approach was used to optimize the perfusion process of a tri-axial bioreactor designed for translational tissue engineering exploiting mechanical stimuli and mechanotransduction. Four controllable design parameters affecting the perfusion process were identified in a cause–effect diagram as potential improvement opportunities. A screening process was use...

During the last decade, the orbital angular momentum (OAM) of light has attracted growing interest as a new degree of freedom for signal channel multiplexing in order to increase the information transmission capacity in today's optical networks. Here we present the design, fabrication and characterization of phase-only diffractive optical elements (DOE) performing mode-division (de)multiplexing...

This paper proposes a methodology that replaces the usual ad hoc approach to metamodeling. This methodology considers validation of a metamodel with respect to both the underlying simulation model and the problem entity. It distinguishes between ®tting and validating a metamodel, and covers four types of goal: (i) understanding, (ii) prediction, (iii) optimization, and (iv) veri®cation and vali...

Background Process optimization deals with various parameters and statistical methods to guarantee consistent cell grow than product quality. Even if high throughput systems can handle these parameter combinations in parallel experiments, the heuristic restriction of boundaries can result in stepwise iterations with many experiments. This can make the way from process development to process est...

A systematic design of experiments (DOE) approach was used to optimize the perfusion process of a tri-axial bioreactor designed for translational tissue engineering exploiting mechanical stimuli and mechanotransduction. Four controllable design parameters affecting the perfusion process were identified in a cause-effect diagram as potential improvement opportunities. A screening process was use...

Design of Experiments (DoE) is an indispensable tool in contemporary drug analysis as it simultaneously balances a number chromatographic parameters to ensure optimal separation High Pressure Liquid Chromatography (HPLC). This manuscript briefly outlines the theoretical background DOE and provides step-by-step instruction for its implementation HPLC pharmaceutical practice. It particularly disc...