Benign fibrous overgrowths are often found in the oral cavity, almost always being reactive/irritational in nature. However, benign mesenchymal neoplasms of the fibroblasts are extremely uncommon. Here we report a case of "True Fibroma of Alveolar Mucosa" for its rarity.

The diagnosis of benign cervical that does not rely on imaging, but the clinical and histological examination. Indeed, the main question is: is it a benign or malignant lesion? Among the benign lesions, the variety of lesions that may be encountered is important. However, knowledge of the typical aspects of the most common injuries helps confirm a diagnosis and avoid unnecessary explorations. L...

Malignant cylindroma (cylindromatous carcinoma, cylindrocarcinoma) is the malignant counterpart of benign cylindroma. It is a rare neoplasm, more often developing in the setting of multiple preexisting benign neoplasms. Herein we present an additional case of malignant transformation of the cylindroma diagnosed in an 83-year-old patient with known Brooke-Spiegler syndrome.

The word “cancer” is perhaps the most feared word in our language. This is largely due to the aggressive nature of this disease, but also because so much is yet unknown about this disease. This lecture will provide an overview of our current understanding of cancer, or more generally, neoplasia. Neoplasia can be defined as a clonal proliferation of cells with somatic genetic alterations and abe...

BACKGROUND To determine in a large series of surgical biopsies the role and significance of immunohistochemistry in the adequate and accurate characterization of malignant tumors. METHODS A retrospective study of 20,000 consecutive surgical biopsies reported in the Section of Histopathology, AKU in 2003. Data was obtained by retrieving the filed surgical biopsy reports in the section. RESUL...

AIMS To determine the role of fine needle aspiration cytology (FNAC) in the diagnosis and management of thyroid disease. METHODS Clinical histories of 144 patients who had undergone FNAC of the thyroid were analysed. Clinical presentation, non-invasive investigations including hormone assays, ultrasound, and isotope scan procedures were compared with FNAC diagnoses in all cases and with histo...

Background: Alpha-smooth muscle actin (α-SMA) is an isoform of actin, positive in myofibroblasts and is an epithelial to mesenchymal transition (EMT) marker. EMT is a process by which tumor cells develop to be more hostile and able to metastasize. Progression of tumor cells is always followed by cell composition and extracellular matrix component alteration. Increased α-SMA expression and colla...

Glomus tumors are neoplasms arising from the glomus body, which regulate skin temperature. They mostly benign and present in subungual area of a distal phalanx. However, they can occur extradigital location, may not be typical intradigital tumors. This makes it difficult to diagnose We report volar tumor mimicking painful ganglion with literature review.

We investigated 16 lymphoid proliferations occurring in the ocular adnexa, salivary glands, breast, and thyroid gland and satisfying the histopathologic and immunophenotypic criteria of benign lymphoid hyperplasia for the presence of clonal rearrangements of the antigen receptor, c-myc, bcl-1, and bcl-2 genes and Epstein-Barr virus (EBV) DNA sequences. Each of these 16 extranodal, noncutaneous ...