A prominent theory states that animal phenotypes arise by evolutionary changes in gene regulation, but the extent to which this theory holds true for behavioral evolution is not known. Because "nature and nurture" are now understood to involve hereditary and environmental influences on gene expression, we studied whether environmental influences on a behavioral phenotype, i.e., aggression, coul...

Despite striking differences in cognition and behavior between humans and our closest primate relatives, several studies have found little evidence for adaptive change in protein-coding regions of genes expressed primarily in the brain. Instead, changes in gene expression may underlie many cognitive and behavioral differences. Here, we used digital gene expression: tag profiling (here called Ta...

Repository-based version control systems such as CVS, RCS, Subversion, and GIT, are extremely useful tools that enable software developers to concurrently modify source code, manage conflicting changes, and commit updates as new revisions. Such systems facilitate collaboration with and concurrent contribution to shared source code by large developer bases. In this work, we investigate a framewo...

Obesity is a multifactorial health problem resulting from genetic, environmental, and behavioral factors. A particularly interesting aspect of obesity is the differences observed in response to the same high-fat diet (HFD). In this study, we performed lipidomic profiling on livers from HFD-fed C57BL/6J mice using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometr...

This chapter provides an overview of the Minnesota Intrusion Detection System (MINDS), which uses a suite of data mining based algorithms to address different aspects of cyber security. The various components of MINDS such as the scan detector, anomaly detector and the profiling module detect different types of attacks and intrusions on a computer network. The scan detector aims at detecting sc...

Dental decay is one of the most prevalent chronic diseases worldwide. A variety of factors, including microbial, genetic, immunological, behavioral and environmental, interact to contribute to dental caries onset and development. Previous studies focused on the microbial basis for dental caries have identified species associated with both dental health and disease. The purpose of the current st...

A cardinal prerequisite for the proper and efficient management of a network, especially an ISP network, is to understand the traffic that it carries. Traffic profiling is a means to obtain knowledge of the traffic behavior. Previous work has been focusing on traffic profiling at the link level or the host level. However, network prefix-level traffic behaviors have not yet been investigated. In...

The popularity of social media platforms such as Twitter has led to the proliferation of automated bots, creating both opportunities and challenges in information dissemination, user engagements, and quality of services. Past works on profiling bots had been focused largely on malicious bots, with the assumption that these bots should be removed. In this work, however, we find many bots that ar...

Circadian rhythms are approximate 24-h behavioral and physiological cycles that function to prepare an organism for daily environmental changes. The basic clock mechanism is a network of transcriptional-translational feedback loops that drive rhythmic expression of genes over a 24-h period. The objectives of this study were to identify transcripts with a circadian pattern of expression in adult...

Delineating the molecular basis of individual differences in the stress response is critical to understanding the pathophysiology and treatment of posttraumatic stress disorder (PTSD). In this study, 7 d after predator-scent-stress (PSS) exposure, male and female rats were classified into vulnerable (i.e., "PTSD-like") and resilient (i.e., minimally affected) phenotypes on the basis of their pe...