This study was designed to evaluate the effects of hypokinesia and hypodynamia on cytoskeletal and related protein contents in human skeletal muscles. Twelve proteins: dystrophin and its associated proteins (DGC), dysferlin, talin, vinculin and meta-vinculin, alpha-actinin, desmin, actin, and myosin, were quantitatively analyzed during an 84-day long-term bedrest (LTBR). The preventive or compe...

Abstract Background Following a hip fracture up to 60% of patients are unable regain their pre-fracture level mobility. For hospitalized older adults, the deconditioning effect bedrest and functional decline has been identified as most preventable cause ambulation loss. Recent studies demonstrate that this adult population spends greater than 80% time in bed during hospitalization, despite bein...

Temporary intracardiac pacing is required for emergency and also certain interventional procedures, including the increasingly indicated transcatheter aortic valve implantation. An important condition use of temporary pacemakers a short procedure time. Current are implanted through veins using fluoroscopy, and, when in situ, bedrest required. As an alternative to this traditional approach, nove...

TO THE EDITOR: We appreciate the opportunity to further discuss the effects of spaceflight on the cerebral circulation. Dr. Zhang’s letter (6) emanates from the multiple observations that in head-down hindlimb-unloaded (HU) rats, an animal model used to simulate microgravity exposure, the cerebral arteries demonstrate greater vasoconstrictor responsiveness and hypertrophic remodeling (e.g., 5) ...

Background & Aims: Preterm labor is often resulted in preterm births and increased rate of neonatal morbidity and mortality. Treatment consists of bedrest, hydration, pharmacologic interventions, and combinations of these. The purpose of this study was to compare the efficacy of intravenous magnesium sulfate (MgSO4) and indomethacin in the treatment of preterm labor pains. Neonatal and maternal...

To better understand disuse muscle atrophy, via magnetic resonance imaging, we sequentially measured muscle cross-sectional area along the entire length of all individual muscles from the hip to ankle in nine male subjects participating in 60-day head-down tilt bed rest (2nd Berlin BedRest Study; BBR2-2). We hypothesized that individual muscles would not atrophy uniformly along their length suc...

We examined the effect of high-load fly-wheel (targeting the lower-limb musculature and concurrent loading of the spine via shoulder restraints) and spinal movement countermeasures against lumbar spine muscle atrophy, disc and spinal morphology changes and trunk isokinetic torque loss during prolonged bed-rest. Twenty-four male subjects underwent 90 d head-down tilt bed-rest and performed eithe...

A review of the literature reveals uniform acceptance of the fact that a relatively large percentage of tuberculosis patients reactivate regardless of extent of disease,8’ 14, 19 type of treatment whether bedrest,’” collapse therapy,9 long1’ or short term chemotherapy or resection.’8 Further, it is accepted that the rate of relapse is usually in proportion to the extent of disease and the amoun...

Introduction: Suicidal jumper’s fracture (unstable sacral fracture) is characterized not only by multiple fractures including thoracolumbar fractures, but also major chest and abdominal injuries. Early stabilization of these fractures and early ambulation are required for the treatment and management of chest and abdominal injuries. We present 3 cases of suicidal jumper’s fracture with thoracol...