The alterations in local cerebral glucose utilisation in eight discrete nuclei in the thalamus following the administration of apomorphine (0.5 mg kg-1) have been investigated with the autoradiographic 2-deoxyglucose technique in 11 conscious rats. In two thalamic nuclei (parafascicular and ventrolateral nuclei), glucose utilisation was significantly elevated following apomorphine; in two thala...

DNA vaccination is a relatively recent development in vaccine methodology. It is now possible to undertake a rational step-by-step approach to DNA vaccine design. Strategies may include the incorporation of immunostimulatory sequences in the backbone of the plasmid, co-expression of stimulatory molecules, utilisation of localisation/secretory signals, and utilisation of the appropriate delivery...

A survey of general practice in the London borough of Lambeth was analysed to discover how the distance from a patient's home to a medical facility affects the utilisation of that facility. It was shown that distance has a negative effect on utilisation for all population groups except men aged 15 to 64. The effect was especially marked for women, for the elderly, and for Social Classes III, IV...

OBJECTIVE The chronic obstructive pulmonary disease (COPD) integrated care pathway (ICP) programme was designed and implemented to ensure that the care for patients with COPD is comprehensive and integrated across different care settings from primary care to acute hospital and home. We evaluated the effectiveness of the ICP programme for patients with COPD. DESIGN, SETTING AND PARTICIPANTS A ...

background: red blood cell and other blood products play a crucial role in management of different disease processes, but in spite of implementation of crucial steps to improve the process of request for blood and blood consumption, there is still not enough information available regarding the proper practice in many medical centres. we aimed to evaluate the status of blood product requests and...

the effect of tillage (conventional and zero tillage), crop establishment (raised-bed and flat-bed), and weed management practices (herbicide alone and integrated approach) was studied on productivity, profitability, nutrient uptake and physico-chemical properties of soil in soybean–wheat cropping system, at new delhi during 2010–2012. sixteen treatment combinations consisting of four tillage a...

The NAIRU is the rate of unemployment consistent with stable inflation... An important challenge in setting economic policy is to identify the rate of capacity utilisation that is sustainable, in the sense that it is associated with reasonably stable inflation. There are different ways of measuring capacity utilisation. Looking at perhaps the most common measure, unemployment, this idea of sust...

The timely article by Verdoux & Begaud ́ hopefully begins to redress the imbalance between randomised controlled trials and other ways of evaluating drug treatments. I would like to present further evidence for the ‘gap between guidelines and utilisation . . . for psychotropic medications’ (Verdoux & Begaud, 2004). ́ Using the Drug Report of the German Public Health Insurance (Schwabe & Pfaffrath...

The major catabolic enzyme for serotonin, monoamine oxidase (MAO), is present in the endothelium of cerebral vessels. We report the effects of the intracarotid administration of serotonin on local cerebral glucose utilisation in rats following MAO inhibition with the drug clorgyline. It was found that saline, clorgyline, or serotonin alone produced no significant changes in glucose utilisation....

In this paper, we re-analyse the Rate Monotonic Scheduler. Traditionally, the schedulability condition was obtained from the greatest lower bound of utilisation factors over all the task sets that (are schedulable and) fully utilise the processor. We argue that full utilisation is not very appropriate for this purpose. We reestablish Liu and Layland’s classic schedulability theorem by finding t...