A simple, rapid procedure for the determination of organic mercury in sediments, plants and fish tissues has been developed and validated. Extraction and separation of organic mercury compounds from the sample matrix was achieved by an established procedure based on an acid leaching of the sample (H2SO4/KBr/CuSO4), followed by extraction of the organic mercury halide with toluene and back-extra...

This study describes the optimization and validation of a quick and simple method for the simultaneous determination of total content and available fractions of As, Cr, Cu, Ni, Pb and Tl in sediments by ET AAS, which has been proved to be useful for environmental research. The optimization was carried out using a 3(3) Box-Behnken factorial design which was applied to matrices of total digestion...

The objectives of the current study are to investigate concentration, biological risks, chemical speciation, and mobility heavy metals also determination their distribution, physicochemical characteristics, abundance microplastics in coastal sediments edible bivalves Persian Gulf, area Hormozgan Province. Sampling points were selected considering location industrial, urban Hara forest protected...

The effect of imatinib mesylate (imatinib) therapy on angiogenesis and myelofibrosis was investigated and compared with interferon (IFN) and hydroxyurea (HU) in 98 patients with newly diagnosed Philadelphia chromosome-positive/BCR-ABL(+) (Ph(+)/BCR-ABL(+)) chronic myeloid leukemia in first chronic phase and no other pretreatment. By means of immunostaining (CD34) and morphometry, a relationship...

As a low cost byproduct, Actinidia deliciosa shell can be made into sorbent materials which are used in heavy metals immobilization. It has been investigated as a replacement for currently expensive methods of heavy metal immobilization from soil. In this study, soil samples were contaminated with copper (Cu) and zinc (Zn) at the rate of 600 ppm in separate dishes. The 5% Actinidia deliciosa sh...

Tyrosine kinases (TKs) play a significant role in cancerogenesis and cancer cell function. Initial developments in this field go back to the early 80s, but the success story really started with the selective BCR-ABL inhibitor, imatinib. Owing to the cancer-driving role of BCR-ABL in chronic myeloid leukemia (CML), excellent response rates lead to fast FDA approval in both the first and second t...

B-lymphocyte development involves sequential DNA rearrangements of immunoglobulin (Ig) heavy (mu) and light (kappa, lambda) chain loci and is dependent on transient expression of mu containing pre-antigen receptor complexes (pre-BCR). To date, genetic analysis has not identified transcription factors that coordinate the pre-B-to-B transition. We demonstrate that the related interferon regulator...

The hallmark of chronic myelogenous leukemia (CML) is the Philadelphia (Ph) chromosome that fuses genetic sequences of the BCR gene on chromosome 22 with c-ABL sequences translocated from chromosome 9. BCR/ABL fusion proteins have a dysregulated protein tyrosine kinase (PTK) activity exerting a key role in malignant transformation. Targeting the tyrosine kinase activity of BCR/ABL or using agen...

Information extraction (IE) is an important problem for information integration with broad applications. It is an attractive application for machine learning. The core of this problem is to learn extraction rules from given input. This paper extends a pattern discovery approach called IEPAD to the rapid generation of information extractors that can extract structured data from semi-structuredWe...

the aim of this study was to determine the extent of metal pollutions and the identification of their major sources in the vicinity of the sangan iron mine occurring in ne iran. soil samples were collected from the vicinity of the mine site and analyzed for heavy metals. in addition, the chemical speciation of these metals was investigated by means of the sequential extraction procedure. the st...