BACKGROUND Although evidence now suggests cGMP is a negative regulator of cardiac hypertrophy, the direct consequences of the soluble guanylyl cyclase (sGC) activator BAY 58-2667 on cardiac remodeling, independent of changes in hemodynamic load, has not been investigated. In the present study, we tested the hypothesis that the NO(•)-independent sGC activator BAY 58-2667 inhibits cardiomyocyte h...

The objectives of this study were to examine surface sediments in the San Francisco Estuary for PAH composition over a range of spatial and temporal scales to determine distributions, trends, and possible sources. Surface sediments (top 5 cm) were collected at 26 sites from 1993 to 2001. The mean total PAH (SPAH) concentration in sediments was spatially distributed as Central Bay (230 mg/kg TOC...

Nutrient and chlorophyll a concentrations and distributions in two adjoining regions of the South Atlantic Bight (SAB), Onslow Bay and nearshore Long Bay, were investigated over a 3-year period. Onslow Bay represents the northernmost region of the SAB, and receives very limited riverine influx. In contrast, Long Bay, just to the south, receives discharge from the Cape Fear River, draining the l...

The in vitro activity of BAY 12-8039, a new fluoroquinolone, was studied in comparison with those of ciprofloxacin, trovafloxacin (CP 99,219), cefpodoxime, and amoxicillin-clavulanate against gram-negative, gram-positive, and anaerobic bacteria. Its activity against mycobacteria and chlamydia was also investigated. BAY 12-8039 was active against members of the family Enterobacteriaceae (MIC at ...

OBJECTIVE to evaluate the protective effects of BAY 41-2272, a soluble guanylate cyclase activator, on changes in cystometric parameters in rats deficient in nitric oxide (NO). METHODS Rats were divided into the following groups: (a) control; (b) DMSO; (c) L-NAME; (d) BAY 41-2272 alone; (e) L-NAME + BAY 41-2272. The NO synthase blocker L-NAME (20 mg/rat/day) was given in drinking water concom...

The efficiency of container handling has got great improvement with the usage of the 40ft quay crane and the twin 40 ft yard crane. Reasonable bay planning strategies is necessary to reach the high handing efficiency by the twin 40 ft yard crane. This paper studies both bay planning and row planning for yard bay allocation. The models of bay planning and row planning are created, and the discre...

In 1957–1959, the introduced protistan parasite, Haplosporidium nelsoni, killed 90–95% of the oysters (Crassostrea virginica) in lower Delaware Bay and about half of those in the upper bay. Shortly thereafter, H. nelsoni-caused mortality in the wild population of the lower bay declined, approximating that of first-generation selectively bred oysters. For nearly three decades thereafter no furth...

Sewage effluent, storm runoff, discharge from polluted rivers, and inputs of groundwater have all been suggested as potential sources of land derived nutrients into Hanalei Bay, Kauai. We determined the nitrogen isotopic signatures (delta(15)N) of different nitrate sources to Hanalei Bay along with the isotopic signature recorded by 11 species of macroalgal collected in the Bay. The macroalgae ...

Surface ozone (O3) was analyzed to investigate the role of the bay breeze on air quality at two locations in Edgewood, Maryland (lat: 39.4°, lon: -76.3°) for the month of July 2011. Measurements were taken as part of the first year of NASA's "Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality" (DISCOVER-AQ) Earth Venture campaign ...