a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

abstract the objective of present study was to evaluate pharmacokinetic parameters of dibudipine phytosolve after oral administration in rats. the solubility test was carried out to select suitable oily solvent for dibudipine. phytosolve formulation was prepared with a medium chain triglyceride (mct) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). the effect of polyol c...

omega-3 fatty acids (fas) have been shown to prevent cardiovascular disease. the most commonly used omega-3 fatty acids like eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) are highly vulnerable to oxidation and therefore, have short shelf life. recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 fas. several methods could be implemented to prepar...

Sometimes it seems as if horror is the only story that science has to tell, or the only one we want to hear. Somebody has a gadget they have to build, an experiment too sweet to resist. .. The tug of war between beauty and horror is the theme of " Doctor Atomic. When I was a boy, I looked out into the star-filled sky one night and was awestruck by its beauty. .. A few days later, I happened on ...

A large scale experimental program using vertical and batter model piles in sand subjected to pull out loads has been carried out in a model tank of size 1m x 1m x 1m. Mild steel pipes of varying diameters, lengths, and shapes are used as model piles. A poorly graded river sand having specific gravity G= 2.67, Uniformity coefficient= 3.53, emax = 0.81, emin = 0.54 has been used as foundation me...

in order to improve local therapeutic techniques for the massively burnt patients and to minimize the pain associated with dressing change, the concept of topical film was utilized to formulate a topical antimicrobial spray. the commonly used topical antimicrobial silver sulfadiazine spray was formulated as a new drug delivery system. the release of therapeutic agents in vitro from medicated sp...