Brain lesions associated with seizures in an epilepsy-prone colony of beagle dogs were studied in 68 dogs which died as a result of the disorder. Approximately 48.5% of the dogs had a relatively specific pattern of acute brain damage on microscopic examination. In all affected areas, there was a triad of lesions consisting of perineuronal and perivascular astrocytic swelling, perineuronal basop...

The arthropod central complex and vertebrate basal ganglia derive from embryonic basal forebrain lineages that are specified by an evolutionarily conserved genetic program leading to interconnected neuropils and nuclei that populate the midline of the forebrain-midbrain boundary region. In the substructures of both the central complex and basal ganglia, network connectivity and neuronal activit...

This report describes the concomitant occurrence of the JC virus (JCV) induced demyelinating disease progressive multifocal leucoencephalopathy (PML) and a primary central nervous system lymphoma (PCNS-L) in a patient with AIDS. Postmortem neuropathological examination revealed characteristic features of PML including multiple lesions of demyelination, enlarged oligodendrocytes with hyperchroma...

The mechanisms controlling the assembly of brain nuclei are poorly understood. In the forebrain, it is typically assumed that the formation of nuclei follows a similar sequence of events that in the cortex. In this structure, projection neurons are generated sequentially from common progenitor cells and migrate radially to reach their final destination, whereas interneurons are generated remote...

That the basal ganglia are related to the control of movement has been known for a long time; diseases affecting primarily the basal ganglia lead to characteristic disturbances of movement and of resting muscle tone. Improved methods for tracing fiber connections have shown, however, that the main efferent connections of the basal ganglia do not descend to motor nuclei in the brain stem and spi...

We have proposed that the basal ganglia act as the central switching mechanism for the action selection system of the vertebrate brain. Simulation of our functional model of basal ganglia demonstrated that their output was consistent with this action selection hypothesis. Here we extend this model by incorporating anatomically-inspired local inhibitory axon collateral networks into two basal ga...

tyrosinase is a multifunctional copper-containing enzyme. it can catalyze two distinct reactions of melanin synthesis and benzaldehyde derivatives, which are potential tyrosinase inhibitors.  to find the relationships between charge distributions of benzaldehyde and their pharmaceutical behavior, the present study aimed at investigating nuclear quadrupole coupling constants of quadrupolare nucl...

The basal ganglia are large subcortical structures comprising several interconnected nuclei in the forebrain, midbrain, and diencephalon (Fig. 31.1). Because of certain features, it is generally agreed that basal ganglia participate in the control of movement. The largest portion of basal ganglia inputs and outputs are connected with motor areas. Second, the discharge of many basal ganglia neur...

The retina of MelYllnis roosevelti Eigenmann, 19 15, a velY active treshwater fish , was investigated by light and electron microscopy and was found to have a complex neuronal structure that allows rapid responses of visual stimuli. Retina photo receptors are double cones, single long cones, single short cones and rods. Cone inner segments are alTanged as mosaics. The outer nuclear layer contai...

Confocal micro-Raman spectroscopy is used to probe the nuclei of normal human epidermal cells and epidermally derived cancer cells from nodular basal cell carcinomas. Clear differences are seen between the spectra. The nuclei of tumor cells appear to have different contributions from nucleic acids, histones, and proteins with an actin-like spectrum than those of normal epidermal cells. Changes ...