The cyanuric acid hydrolase, AtzD, is the founding member of a newly identified family of ring-opening amidases. We report the first X-ray structure for this family, which is a novel fold (termed the 'Toblerone' fold) that likely evolved via the concatenation of monomers of the trimeric YjgF superfamily and the acquisition of a metal binding site. Structures of AtzD with bound substrate (cyanur...

The evoked effects of the negatively charged drugs phenobarbital and barbituric acid, the positively charged imipramine, perphenazine and trifluoperazine, and the neutral primidone, on the synaptosome-associated acetylcholinesterase activity were studied. A marked increase in the enzyme activity was exhibited in the presence of low concentrations (up to 3 mM) of phenobarbital, barbituric acid a...

Abstract A set of C 3 N 4 samples has been prepared by using melamine, cyanuric acid and barbituric as the precursors. The materials were subjected both to physical chemical characterization used photocatalysts for selective oxidation aromatic alcohols in water suspension under UV visible irradiation. photoactivity versus partial four substituted benzyl was investigated. type position substitue...

Thanks to the in silico approach drug design, identification of new molecules is enabled and facilitated, as well optimization pharmacokinetics toxicity compounds obtained from different sources. Chromatographic methods, on other hand, provide accurate reliable information influence nature substituents applied organic modifiers pharmacological behavior compounds, relying existence similarities ...

Abstract A highly efficient, fast, catalyst‐free, and atom economical method was developed for the synthesis of 5‐benzylidenebarbiturates. Thus, reacting barbituric acid aldehydes in water as a green solvent under electrochemical conditions afforded target compounds six minutes pure forms. The effects solvent, reaction time, temperature, electrolyte, electrode material were studied to optimize ...

An electroorganic reaction for the synthesis of 7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-pyrano[2, 3-d] pyrimidine-6-carbonitrile and ethyl-7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-pyrano[2, 3-d] pyrimidine-6-carboxylate derivatives are described, using an electrogenerated base of the anion of malonitrile or ethylcyanoacetate. This one-pot, three-component condensation of an a...

The tetra-gonal polymorph of 5,5-dichloro-barbituric acid (m.p. 478 K), C(4)H(2)Cl(2)N(2)O(3), forms an N-H⋯O hydrogen-bonded tape structure along [001]. Two tapes related by a twofold rotation axis are associated via Cl⋯O contacts [3.201 (1) Å], and four such chain pairs are arranged around a fourfold roto-inversion axis. The crystal structures of the monoclinic and ortho-rhom-bic polymorphs h...