Aberrant methylation has been shown to trigger the inactivation of tumor suppressor genes during tumorigenesis. MicroRNAs (miRNAs) have been found deregulated in human colorectal cancer (CRC), and some of them may function as tumor suppressor genes. Here, we investigated CpG island promoter hypermethylation as a potential mechanism underlying miRNA disruption and identifed methylation-sensitive...

Aim Cytokine-induced neutrophil chemoattractant (CINC/gro) is a CXC family chemokine, similar to interleukin-8 in rats, and is one of the factors that regulates ovulation. However, the mechanism that regulates atresia of the ovaries postovulation is not clearly defined. Methods Whether antibody-blocking of CINC/gro can alter the number of ovulated oocytes and modulate neutrophil infiltration ...

The nonstructural protein 2 (NSP2) is considered to be one of crucial viral proteins in the replication and pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV). In the present study, the host cellular proteins that interact with the NSP2 of PRRSV were immunoprecipitated with anti-Myc antibody from the MARC-145 cells infected by a recombinant PRRSV with 3xMyc tag insertio...

JC virus, JCV, is a human neurotropic polyomavirus whose replication in glial cells causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). In addition, JCV possesses oncogenic activity and expression of its transforming protein, large T-antigen (T-Ag), in several experimental animals induces tumors of neural origin. Further, the presence of JCV DNA and T-Ag hav...

The Bcl-2 oncoprotein is a key regulator of apoptosis and the Bag-1 protein interacts with Bcl-2 and cooperates with Bcl-2 to suppress apoptosis. The human Bag-1 cDNA is essentially identical with a previously described cDNA encoding RAP46, which interacts with activated steroid hormone receptors. However, there is considerable confusion over the structure of Bag-1/RAP46 proteins and their rela...

RATIONALE A homozygous disruption or genetic mutation of the bag3 gene, a member of the Bcl-2-associated athanogene (BAG) family proteins, causes cardiomyopathy and myofibrillar myopathy that is characterized by myofibril and Z-disc disruption. However, the detailed disease mechanism is not yet fully understood. OBJECTIVE bag3(-/-) mice exhibit differences in the extent of muscle degeneration...

http://dx.doi.org/10.1016/j.pmip.2016.11.003 2468-1717/ 2016 Elsevier Inc. All rights reserved. Abbreviations: BD, bipolar disorder; CSF, cerebrospinal fluid; BDNF, brain-derived neurotrophic factor; NT3, neurotrophin-3; NT4, neurotrophin-4; NGF, nerve factor; Trk, tyrosine kinase receptor; p75, TNF receptor superfamily member 1B; CNS, central nervous system; MDD, major depressive disorder; DLP...

The present study was aimed to investigate the role of reactive oxygen species (ROS) on advanced glycation end product (AGE)-induced proliferation and migration of vascular smooth muscle cells (VSMCs) and whether Bcl-2‑associated athanogene 3 (BAG3) is involved in the process. Primary rat VSMCs were extracted and cultured in vitro. Cell viability was detected by MTT assay and cell proliferation...

The chronic high-level alcohol consumption seen in alcoholism leads to dramatic effects on the hippocampus, including decreased white matter, loss of oligodendrocytes and other glial cells, and inhibition of neurogenesis. Examining gene expression in post mortem hippocampal tissue from 20 alcoholics and 19 controls allowed us to detect differentially expressed genes that may play a role in the ...

HomePlant DiseaseVol. 105, No. 6First Report of Cucurbit Chlorotic Yellows Virus in Association with Other Whitefly-Transmitted Viruses Yellow Squash (Cucurbita pepo) Georgia, U.S.A. PreviousNext DISEASE NOTES OPENOpen Access licenseFirst U.S.A.Saritha Raman Kavalappara, Hayley Milner, Alton Sparks, Cecilia McGregor, William M. Wintermantel, and Sudeep BagSaritha KavalapparaDepartment Plant Pat...