objective(s) the purpose of the present study was to use the solid dispersion (sd) technique to improve the dissolution rates of indomethacin (imc). materials and methods imc solid dispersions in pvp k30 and isomalt (galen iq 990) were prepared using the solvent evaporation technique and a hot melt method in weight ratios of 2, 10 and 30% (imc:pvp). solid dispersions and physical mixtures were ...

Segregation of images into figures and background is fundamental for visual perception. Cortical neurons respond more strongly to figural image elements than to background elements, but the mechanisms of figure-ground modulation (FGM) are only partially understood. It is unclear whether FGM in early and mid-level visual cortex is caused by an enhanced response to the figure, a suppressed respon...

the purpose of the present study was to determine whether noticing through input enhancement had any impact on the acquisition of english conditional sentences in iranian efl learners. two intact classes with 26 female students in each were chosen. a proficiency test administered at the commencement of the study showed that the two groups were homogeneous in terms of their language proficiency....

Background Late Gadolinium enhancement represents a widely employed method for detecting myocardial scarring e.g. after myocardial infarction or for myocardial Inflammation. A frequent finding is slight basal septal enhancement as well as intramyocardial enhancement, mostly referred as myocardial fibrosis. Less is known about the impact on myocardial conduction and a possible correlation to ECG...

OBJECTIVE To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM). METHODS 146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to the high-risk cases on the basis of age. The correlation of BPE with factors such as fibroglandula...

BACKGROUND While many studies have shown that hormones can influence background parenchymal enhancement (BPE) in breast magnetic resonance imaging (MRI), only few have directly address the effect of radiotherapy. The purpose of this study was to evaluate the impact of radiotherapy on BPE in breast MRI. MATERIALS AND METHODS A retrospective search identified 62 women with unilateral breast can...

This retrospective study assessed the effects of menopausal status and menstrual cycle on background parenchymal enhancement (BPE) of breast magnetic resonance imaging (MRI), and investigated whether the degree of BPE can be predicted by findings of mammography, ultrasonography (US), and diffusion-weighted MR imaging (DWI). There were 160 study patients (80 premenopausal, 80 postmenopausal). De...

Sensory extension and increasingly powerful computation underpinning emerging new science provides us with daunting conceptual challenges. It is here argued that because they are primarily philosophical in nature, high-level conceptual challenges are unique and different from those that help us refine outputs and achievements based on solving our technical and political problems. This paper exp...

Background:Mammographic dense breast or high background parenchymal enhancement (BPE) in magnetic resonance imaging (MRI)hinders diagnostic accuracy for breast tumor detection. We retrospectively investigated relationship between BPE on MRI and mammographic densities along with the influential factors. Methods:Our study included 144 Japanese women who underwent both mammography and breast MRI u...

Regardless of the administration route, the key factor for the success and reliability of any formulation is drug bioavailability, defined as the rate and extent at which the active drug is absorbed from a pharmaceutical form and becomes available at the site of drug action.1 Although metabolism and physiological factors highly affect drug absorption by living tissues, bioavailability is strong...