OBJECTIVE To evaluate tolerability, safety, and quality-of-life outcomes in non-opioid-pretreated patients with severe chronic low back pain with a neuropathic component receiving tapentadol PR vs. oxycodone/naloxone PR. METHODS Eligible patients (average pain intensity [numerical rating scale] ≥ 6; painDETECT positive/unclear ratings) were randomized to twice-daily tapentadol PR 50 mg or oxy...

BACKGROUND The efficacy of ALO-02, an abuse-deterrent formulation containing extended-release oxycodone and sequestered naltrexone, in the treatment of chronic low back pain (CLBP) was studied in a 12-week randomized controlled trial. Primary efficacy endpoint results have been published previously (Rauck et al., 2015). The current paper focuses on patient-reported outcomes for health-related q...

Bee venom acupuncture (BVA) is an effective treatment for chronic low back pain (CLBP) through the pharmacological effects of bee venom and the simultaneous stimulation of acupoints. However, evidence of its efficacy and safety in humans remains unclear. Using a double-blind, randomized study, 54 patients with non-specific CLBP were assigned to the BVA and sham groups. All participants underwen...

BACKGROUND Many chronic low back pain (cLBP) patients do not satisfactorily respond to treatment. The knowledge of responders and non-responders before initiating treatment would improve decision making and reduce health care costs. The aims of this exploratory prediction study in cLBP patients treated with tapentadol were to identify predictors of treatment outcome based on baseline characteri...

The identification process of gas flavor is conducted by using the output of gas sensor system to recognize a variety of gas flavor. The identification and analysis process of this system is processed by using an artificial neural network approaches those are back propagation and Kohonen method. According of the experiment’s result, the best parameter for back propagation network is the momentu...

sandwich sheet rolling process is investigated using an analytical method (slab method) and a numerical method (finite element method). the horizontal stress distribution in the layers, the rolling pressure along the contact interface and the neutral point between the roll and the sheet are investigated. then the affects of the parameters such as the friction between the sheet and the roll, she...

background: low back pain caused by work, ranked the second after cardiovascular diseases, are among the most common reasons of patients’ referral to the physicians in iran. this study aimed to determine the changes in back compressive force when measuring maximum acceptable weight of lift in iranian male students. methods: this experimental study was conducted in 2015 on 15 young male students...

The parameters of the constitutive model, the creep model, and the wetting model of materials of the Nuozhadu high earth-rockfill dam were back-analyzed together based on field monitoring displacement data by employing an intelligent back-analysis method. In this method, an artificial neural network is used as a substitute for time-consuming finite element analysis, and an evolutionary algorith...

exposure to welding gases can cause health adverse effects. risk assessment is a useful tool for good assessment of exposed workers. the purpose of this study was to determine the risk levels for exposed welders to welding gases. welders (n=239) were selected from iranian natural gas transmission pipelines industry from four regions in iran including assaluyeh, omidieh, loshan, and borujen. ozo...