نتایج جستجو برای: bace 1
تعداد نتایج: 2752751 فیلتر نتایج به سال:
Journal:
:research in pharmaceutical sciences
0
Journal:
:Annual Research & Review in Biology
2018
Journal:
:Bioorganic & Medicinal Chemistry Letters
2010
Journal:
:Journal of Computational Chemistry
2017
Journal:
:Acta Pharmacologica Sinica
2009
Journal:
:Journal of Biological Chemistry
2004
Journal:
:Developmental Neurobiology
2017
Journal:
:The Open Medicinal Chemistry Journal
2015
2012
Robin L. Webb
M. Paul Murphy
Individuals with Down Syndrome (DS), or trisomy 21, develop Alzheimer's disease (AD) pathology by approximately 40 years of age. Chromosome 21 harbors several genes implicated in AD, including the amyloid precursor protein and one homologue of the β-site APP cleaving enzyme, BACE2. Processing of the amyloid precursor protein by β-secretase (BACE) is the rate-limiting step in the production of t...
Journal:
:ACS Medicinal Chemistry Letters
2014
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