Phosphorothioated oligonucleotides have a sequence-independent antiviral activity as amphipathic polymers (APs). The activity of these agents against herpesvirus infections in vitro and in vivo was investigated. The previously established sequence-independent, phosphorothioation-dependent antiviral activity of APs was confirmed in vitro by showing that a variety of equivalently sized homo- and ...

DNA helicases catalyze separation of double-helical DNA into its complementary single strands, a process essential for DNA replication, recombination, and repair. The Escherichia coli Rep protein, a superfamily 1 DNA helicase, functions in DNA replication restart and is required for replication of several bacteriophages. Monomers of Rep do not display helicase activity in vitro; in fact, DNA un...

Listeria monocytogenes strains possess short repetitive extragenic palindromic (REP) elements and enterobacterial repetitive intergenic consensus (ERIC) sequences. We used repetitive element sequence-based PCR (rep-PCR) to evaluate the potential of REP and ERIC elements for typing L. monocytogenes strains isolated from humans, animals, and foods. On the basis of rep-PCR fingerprints, L. monocyt...

(Hales, J. R. S., eds.), pp. 169-173, Raven Press, New York Nedergaard, J., Alexson, S. & Cannon, B. (1980) Am. J . Physiol. 239, C208Z2 16 Nedergaard, J., Connolly, E., NBnberg, E. & Mohell, N. (1984) Biochem. Soc. Trans. 12, 393-396 Nedergaard, J., Connolly, E. & Cannon, B. (1986) in Brown Adipose Tissue (Trayhurn, P. & Nicholls, D. G., eds.), Edward Arnold, London, in the press Raasmaja, A.,...

Myocardial injury is increased in the aged heart following ischemia-reperfusion (ISC-REP) compared to adult hearts. Intervention at REP with ischemic postconditioning decreases injury in the adult heart by attenuating mitochondrial driven cell injury. Unfortunately, postconditioning is ineffective in aged hearts. Blockade of electron transport at the onset of REP with the reversible inhibitor a...

A central methodological problem in programming with multiple levels of abstractions is the loosely defined problem of rep exposure. This paper traces the problem of rep exposure to the precisely defined notion of abstract aliasing. The paper also outlines a statically-enforceable discipline for avoiding abstract aliasing, but the outline is incomplete.

1 Introduction K-Rep is an object-oriented knowledge representation system based on description logic Woods and Schmolze, 1992]. K-Rep provides a language to express descriptions (e.g., of medical concepts such as drugs, treatments, and diseases), inference mechanisms for reasoning about descriptions and their relationship to one another, and considerable supporting infrastructure. This paper p...

DNA-binding repressors are involved in transcriptional repression in many organisms. Disabling a repressor is a crucial step in activating expression of desired genes. Thus, several mechanisms have been identified for the removal of a stably bound repressor (Rep) from the operator. Here, we describe an uncharacterized mechanism of noncanonical DNA binding and induction by a Rep from the tempera...

Our goal is to create a CAD system dedicated to WWW. Classical CAD systems carry a huge data volume. Because of WWW, its transfer is a main problem, for which no specific method exists. We study the transmission of the three main models in CAD: CSG, octree and B-Rep and show their limits, which can be pushed back by a functional model.