We show that histone deacetylase (HDAC) inhibitors lead to functional expression of MHC class I–related chain A and B (MICA/B) on cancer cells, making them potent targets for natural killer (NK) cell–mediated killing through a NK group 2, member D (NKG2D) restricted mechanism. Blocking either apoptosis or oxidative stress caused by HDAC inhibitor treatment did not affect MICA/B expression, sugg...

Some cases of pre-B cell acute lymphoblastic leukemia (pre-B-ALL) are caused by the Philadelphia (Ph) chromosome-encoded BCR-ABL oncogene, and these tend to have a poor prognosis. Inhibitors of the PI3K/AKT pathway reduce BCR-ABL-mediated transformation in vitro; however, the specific PI3K isoforms involved are poorly defined. Using a murine model of Ph+ pre-B-ALL, we found that deletion of bot...

SARS-CoV-2, the seventh coronavirus known to infect humans after 229E, NL63, 0C43, HKU1, MERS-CoV, and original SARS-CoV, has a large positive-stranded RNA genome of 29,891 nucleotides 9,860 amino acids. It is strain that causes COVID 19. was first discovered in Chinese city Wuhan. undergoes several mutations hence posing great difficulty finding suitable inhibitor. This studies previous potent...

Leflunomide is an immunosuppressive drug capable of inhibiting T and B cell responses in vivo. A number of studies demonstrate that leflunomide functions both as a pyrimidine synthesis inhibitor and as a tyrosine kinase inhibitor. We previously reported that leflunomide inhibits LPS-stimulated B cell proliferation, cell cycle progression, and IgM secretion. This inhibition can be reversed by th...

Cyclopentenone prostaglandins are potent inhibitors of nuclear factor– B (NFB), a transcription factor with a critical role in promoting inflammation and connected with multiple aspects of oncogenesis and cancer cell survival. In the present report, we investigated the role of NFB in the antineoplastic activity of the cyclopentenone prostaglandin 15-deoxy-PGJ2 (15d-PGJ2) in multiple myeloma (MM...