In metastatic colorectal cancer (mCRC) the choice of treatment should take into account characteristics tumor and patient, as well its efficacy tolerability. The RECOURSE study demonstrated that presence low burden indolent disease has an impact on progression-free (PFS) overall (OS) survival patients treated with trifluridine/tipiracil (TAS-102). Retrospective included mCRC undergoing TAS-102 ...

Abstract Study question Which add-ons are effective and safe to use in the ART clinic? Summary answer More than thirty recommendations were formulated on of diagnosis diagnostic tests, laboratory tests intervention, clinical management. What is known already Treatment not essential for treatment but optional additional treatments that sometimes offered top routine fertility treatment. There a w...

Abstract High pharmaceutical pricing practices in Europe have been increasingly on the radar of European Union, academia and civil society as a risk to Member State health budgets. It is therefore hardly surprising that, recent years, competition authorities resuscitated excessive prohibition contained Article 102(a) TFEU. Focusing this phenomenon, piece highlights diverse ways which United Bra...

McCafferty, Donna-Marie, Elaine Sihota, Marcelo Muscara, John L. Wallace, Keith A. Sharkey, and Paul Kubes. Spontaneously developing chronic colitis in IL-10/ iNOS double-deficient mice. Am J Physiol Gastrointest Liver Physiol 279: G90–G99, 2000.—Mice deficient in both inducible nitric oxide synthase (iNOS) and interleukin (IL)-10 (iNOS2/2/IL-102/2) were created to examine the role of iNOS in s...