We examine the competitiveness of Hungarian agriculture in relation to that of the EU, based on four indices of revealed comparative advantage, for the period 1992 to 1998. Consistency tests suggest that the indices are less satisfactory as cardinal and ordinal measures, but are useful in identifying whether or not Hungary has a comparative advantage in a particular product group. Despite signi...

The rostral fastigial nucleus (FNr) of the cerebellum facilitates the respiratory response to hypercapnia. We hypothesized that some FNr sites are chemosensitive to focal tissue acidosis and contribute, at least partially, to respiratory modulation. Minute ventilation (VE) was recorded in 21 anesthetized and spontaneously breathing rats. Acetazolamide (AZ; 50 microM) was microinjected unilatera...

Pretreatment of J774 mouse macrophages by the dicationic macrolide antibiotic, azithromycin (AZ), selectively inhibited fluid-phase endocytosis of horseradish peroxidase and lucifer yellow, but not phagocytosis of latex beads. AZ delayed sequestration of receptor-bound transferrin and peroxidase-anti-peroxidase immune complexes into cell-surface endocytic pits and vesicles, but did not slow dow...

Háttér és célkitûzés – A központi idegrendszerben az átvágással vagy roncsolással elôidézett axondegenerációnak két típusa van: a „sötét” (dark) és a „világos” (watery) axondegeneráció. Azt vizsgáltuk, hogy a „sötét” axondegeneráció létrejöttének mechanizmusa hasonlít-e a „sötét” idegsej tekéhez. Módszerek – Egyetlen kis sérülést okoztunk patkányagy frontoparietalis agykérgében. Az ezt követô e...

Seed shattering is an important agricultural trait in crop domestication. SH4 (for grain shattering quantitative trait locus on chromosome 4) and qSH1 (for quantitative trait locus of seed shattering on chromosome 1) genes have been identified as required for reduced seed shattering during rice (Oryza sativa) domestication. However, the regulatory pathways of seed shattering in rice remain unkn...

The aim of the present study was to determine whether acetazolamide (AZ) contributes to the inhibition of the fast inactivating transient K(+) current (I(A) ) in adult rat nodose ganglion (NG) neurons. We have previously shown that pretreatment with either AZ or 4-AP attenuated or blocked the CO(2) -induced inhibition of slowly adapting pulmonary stretch receptors in in vivo experiments. The pa...

Neurotransmitter is released from synaptic vesicles at the highly specialized presynaptic active zone (AZ). The complex molecular architecture of AZs mediates the speed, precision and plasticity of synaptic transmission. Importantly, structural and functional properties of AZs vary significantly, even for a given connection. Thus, there appear to be distinct AZ states, which fundamentally influ...

High-throughput RNAi screening identifies a role for TNK1 in growth and survival of 1 pancreatic cancer cells 2 3 Meredith C. Henderson, Irma M. Gonzales, Shilpi Arora, Ashish Choudhary, Jeffrey M. 4 Trent, Daniel D. Von Hoff, Spyro Mousses, David O. Azorsa 5 6 Clinical Translational Research Division, The Translational Genomics Research Institute, 7 Phoenix, AZ, 85004, USA 8 Pharmaceutical Gen...

Tropomyosin-related kinases (TrkA, TrkB, and TrkC) are receptor tyrosine kinases that, along with their ligands, the neurotrophins, are involved in neuronal cell growth, development, and survival. The Trk-neurotrophin pathway may also play a role in tumorigenesis through oncogenic fusions, mutations, and autocrine signaling, prompting the development of novel Trk inhibitors as agents for cancer...