Smith-Magenis syndrome (SMS) is a rare syndrome with multiple congenital malformations, including development and mental retardation, behavioral problems and a distinct facial appearance. SMS is caused by haploinsufficiency of RAI1 (deletion or mutation of RAI1). We describe an eight-year-old female Chinese patient with multiple malformations, congenital heart defect, mental retardation, ...

The disease oligophrenia phenylpyruvica (phenylketonuria) presents a unique opportunity for the study of the relation of amino acid metabolism to the function of the central nervous system. In this inborn error of metabolism, which is inherited as a Mendelian recessive character, mental deficiency is accompanied by faulty phenylalanine metabolism. The metabolic disturbance was first recognized ...

5-HT contents of the brain. The possibility exists that some other indole products of the tumour or unidentified intermediary metabolites of 5-HT, having structural similarity, may behave in the same way and are capable of producing mental change. Whatever mechanism may be involved for the cerebral metabolism of serotonin, in the light of the above experimental evidences, and in the absence of ...

Levels of morbidity in 789 children 7 to 11 years of age attending two primary care pediatric clinics in a health maintenance organization were examined in relation to psychiatric disturbance. Physical morbidity was measured as mean number of illness episodes per year enrolled, based on the child's medical record. Two measures of psychiatric disturbance were compared: the pediatricians' judgmen...

This article refers to the International Classification of Diseases 10th edition (ICD-10) which is the official classification system for mental health professionals working in NHS clinical practice. The literature occasionally refers to the Diagnostic and Statistical Manual of Mental Disorders (DSM) classification system which whilst used in clinical practice in the USA is primarily used for r...

from England and Wales report physical and sexual assault by a current or former partner; when financial and emotional abuse and threats of abuse are included, this increases to 25% of women. Two women are murdered by their partner or ex-partner every week in England and Wales and similar figures are reported internationally. One in seven men in the UK also report experiencing physical assault ...

CONTEXT Several investigations have postulated that the perimenopause may represent a period of increased psychiatric vulnerability, particularly for mood disorders. This review characterizes the perimenopause, including biological changes, the influence of psychosocial factors and the most common clinical manifestations. Clinic-based studies and community-based surveys addressing the prevalenc...

Objective: Breast cancer as a most common invasive cancer in women, provoking mental disorders for patients. To adjust with this situation, patients use kind of coping style. In present study, we aimed to determine the relationship between mental disorders and coping style in women with breast cancer.  Methods: This research was a correlational study. 127 women among all women with breast ca...

Children and adolescents with emotional disturbance (ED) exhibit chronic and diverse academic, emotional, behavioral, and/or medical difficulties that pose significant challenges for their education and treatment in schools. Historically, children with ED have received fragmented inadequate interventions and services that often yielded unfavorable school and community outcomes. Numerous child/f...

Menopause is a universal experience for women that occur, in around 50 years old. In this periods women encounter with many changes in their life. Retirement and children leaving home can cause the loneliness and depression, however this time is an opportunity for women to changing their life. The women perception of menopause depends on their social, cultural, economical status and life style ...