نتایج جستجو برای: avermectins
تعداد نتایج: 151 فیلتر نتایج به سال:
Canine and feline heartworm diagnostic, treatment and prevention strategies have changed during the previous decade. We experienced an unprecedented increase in the numbers and kinds of available medications and diagnostic aids, and also in the capabilities of pet owners to acquire information. This can be both beneficial and detrimental in our efforts to establish and maintain effective strate...
The avermectin analog doramectin (CHC-B1), sold commercially as Dectomax, is biosynthesized by Streptomyces avermitilis. aveC, a gene encoding an unknown mechanistic function, plays an essential role in the production of doramectin (avermectin CHC-B1), modulating the production ratio of CHC-B1 to other avermectins, most notably the undesirable analog CHC-B2. To improve the production ratio for ...
Avermectins are commercially important anthelmintic antibiotics produced by Streptomyces avermitilis. The homologous TetR-family transcriptional regulators AvaR1 and AvaR2 in this species were identified previously as receptors of avenolide, a novel butenolide-type autoregulator signal required for triggering avermectin biosynthesis. AvaR2 was found to be an important pleiotropic regulator in r...
BACKGROUND Ivermectin, an acaricide and anthielmintic drug of the family of avermectins may produce free radicals thus resulting cytotoxic effect on the parasite. Nitric oxide (NO) acts as free radicals and as host defense mechanisms. The antioxidant capacity (TAC) can be described by the analysis of single components in the defense systems against free radicals. It was aimed to study the effec...
BACKGROUND Ivermectin (Mectizan, Merck and CO. Inc.) is being widely used in the control of human onchocerciasis (Onchoverca volvulus) because of its potent effect on microfilariae. Human studies have suggested that, at the standard dose of 150 microg/kg an annual treatment schedule of ivermectin reversibly interferes with female worm fertility but is not macrofilaricidal. Because of the import...
Triple-negative breast cancers (TNBC) lacking estrogen, progesterone, and HER2 receptors account for 10% to 20% of breast cancer and are indicative of poor prognosis. The development of effective treatment strategies therefore represents a pressing unmet clinical need. We previously identified a molecularly targeted approach to target aberrant epigenetics of TNBC using a peptide corresponding t...
The effects of various insecticides on the fluidity of mitochondrial membranes and cross-resistance were investigated in the diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae) using strains that were both resistant and susceptible to avermectin. The resistant strain of P. xylostella, AV-R, developed 1078-fold resistance to avermetins with a high level of cross-resistance to t...
The avermectins, milbemycins and spinosyns are collectively referred to as macrocyclic lactones (MLs) which comprise several classes of chemicals derived from cultures of soil micro-organisms. These compounds are extensively and increasingly used in veterinary medicine and agriculture. Due to their potential effects on non-target organisms, large amounts of information on their impact in the en...
Excitatory ionotropic and metabotropic glutamate receptors are found throughout the animal kingdom, but inhibitory ionotropic glutamate receptors seem to be confined to invertebrates (reviewed in [l]). Molecular studies on all invertebrate receptors have lagged far behind those of their mammalian counterparts, but recently interest in the glutamate-gated C1channels (Glu-Cl) has been greatly sti...
Phaseout of the fumigant methyl bromide, restrictions on organophosphates, environmental problems with neonicotinoids and pyrethroids, pest resistance, and the exponential growth of organic agriculture has created a market for alternatives (Weston et al. 2004; Moran 2010; Quarles 2011ab; 1993a). Beneficial nematodes, Bacillus thuringiensis (BT), and a large array of fungi, viruses, and bacteria...
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