New findings in the platypus and Drosophila pseudoobscura illustrate, yet again, that the sex chromosomes seem never to stop evolving. Degeneration processes lead to a continual loss of genes and gene activity on the Y chromosome, and complete loss of Y-linked genes is possible if autosomal genes take over control of male fertility - though addition of new material to the sex chromosomes may st...

objective: the present retrospective study aims at identifying the prevalence of chromosomal abnormalities in a population of couples who are candidates for assisted reproductive techniques. materials and methods: cytogenetic analysis was performed according to the standard methods on cultured cells from the patients’ peripheral blood. the culture, was harvested after 72 hours. at least 20 meta...

Scores of 83 pairs o f twins and their parents on the Cubes Comparison Test have been analyzed to test competing hypotheses about the origin o f individual differences in spatial orientation. Models allowing for polygenic sex-linked or sex-limited gene expression show no improvement in fit over the simple autosomal additive polygenic model. However, individual environmental influences (E 1) acc...

Where previously described, patterns of sex chromosome dosage compensation in the Lepidoptera (moths and butterflies) have several unusual characteristics. Other female-heterogametic (ZW/ZZ) species exhibit female Z-linked expression that is reduced compared with autosomal expression and male Z expression. In the Lepidoptera, however, Z expression typically appears balanced between sexes but ov...

B ECAUSE triploid females form large numbers of chromosomally unbalanced eggs it is possible to recover complementary types of unbalanced sperm. This technique revealed the occurrence of autosomal nondisjunction in males (STERN 1934; PONTECORVO 1940) and was also used by MULLER and PONTECORVO ( 1940) and PONTECORVO (1943) to recover sperm where radiation induced chromosome breaks caused one or ...

Abstract Background Autosomal dominant Alzheimer's Disease (ADAD) is an important area of study to understand the pathogenesis AD. Previous studies suggested that mutations in genes coding for amyloid precursor protein cause early deposition amyloid‐β peptide (Aβ), resulting amyloid‐induced inflammatory response and cortical microstructural changes during cognitively asymptomatic phase, several...

We explored five sex-specific quality control filters in North American Rheumatoid Arthritis Consortium's Illumina 550 k datasets. Three X chromosome and three autosomal single-nucleotide polymorphisms flagged by sex quality control filters were missed by filters of call rate at 95% and Hardy-Weinberg equilibrium at 10-6. We applied a subset of these sex-specific quality control filters to eigh...