tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. to date, there is no information on the pharmacokinetics of tacrolimus in iranian liver transplant recipients. this study was designed to determine pharmacokinetic properties of orally administe...

purpose: to evaluate the effect of amniotic membrane transplantation in trabeculectomy. methods: the study was conducted on 25 eyes of 25 patients with advanced and medically uncontrolled glaucoma. all patients underwent trabeculectomy with a fornix based conjunctival flap, amniotic membrane was then placed under the scleral flap and fixed using 10-0 nylon suture. amniotic membrane was retrieve...

conclusions although the patients carrying m204i mutation were more likely to show lack of responses to lam therapy, lam replacing by other nucleoside/tide analogs plus hbig maybe still effective in decreasing hepatitis b recurrence after liver transplantation. however, it is suggested that drug resistance test should be considered by clinicians during therapeutic management to avoid the follow...

severe combined immunodeficiency is a true pediatric emergency; children with scid were the first patients with immunodeficiencies to be successfully transplanted with unrelated and t-cell-depleted, haploidentical bone marrow. the pattern of inheritance of scid is x-linked and autosomal recessive (ada def, jak3, rag1, rag2, il 7rα). in this case report, we describe a one-year-old boy with b+t- ...

conclusions although iranian publications in the field of nephrology and urology have had a considerable and significant increase in the recent years amongst the middle eastern countries, there is a wide distance to be a science exporter country. results the total number of publications in the field of nephrology and urology was 3,771 (average of 189 papers per year). most of the iranian nephro...

Background: Monitoring of phenotypic characteristics of T-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients.   Objective: To predict rejection in renal transplantation by immune parameters. Methods: 16 non-diabetic kidney transplant candidates (4 females and 12 males, age = 20-65 yr, first time transplant) wer...

Background: Follicular pool is reduced after transplantation of vitrified ovary. Therefore, methods should be improved to accelerate ovarian function revival and maintain follicular reserve. In this study hyaluronic acid hydrogel as a scaffold was used to improve restoration of ovarian oestrous cycle. Materials and Methods: 79 mature (~8 weeks) rats having normal estrous cycles were divided int...