Full thickness articular cartilage defects have limited regenerative potential and are a significant source of pain and loss of knee function. Numerous treatment options exist, each with their own advantages and drawbacks. The goal of this review is to provide an overview of the problem of cartilage injury, a brief description of current treatment options and outcomes, and a discussion of the c...

The laryngotracheal cartilage is a cardinal framework for the maintenance of airway breathing, which occasionally requires reconstruction. Because hyaline has poor intrinsic regenerative ability, various approaches have been attempted to regenerate cartilage. use autologous mesenchymal stem cells (MSCs) regeneration widely investigated. However, long-term culture may limit proliferative capacit...

We propose a culture-free approach to osteochondral repair with minced autologous cartilage fragments loaded onto a scaffold composed of a hyaluronic acid (HA)-derived membrane, platelet-rich fibrin matrix (PRFM) and fibrin glue. The aim of the study was to demonstrate in vitro the outgrowth of chondrocytes from cartilage fragments onto this scaffold and, in vivo, the formation of functional re...

Articular cartilage repair is a continually evolving and often controversial area of sports medicine as the result of variable outcomes, contrasting opinions, and lack of a single reliable resurfacing option in this often complex heterogeneous patient population. Although many articular cartilage lesions are asymptomatic, others cause significant disability in patients who are not optimal candi...

OBJECTIVE To assess long-term outcomes of osteocartilaginous transplantation for non-degenerative lesions of hyaline articular cartilage in the knee, by performing minibiopsies from the transplanted area and examining them histopathologically. PATIENTS AND METHODS Forty-four patients with post-traumatic cartilage injuries of the bearing surfaces of the knee were enrolled in a prospective stud...

INTRODUCTION Augmentation rhinoplasty could be defined as the method whose goal is to increase the dimensions of the nasal pyramid, both the dorsum and the tip. For a long time, surgeons have used different kinds of materials that have often been the object of discussion. The aim of this study is to report our experience with augmentation septorhinoplasty, emphasising the type and nature of the...

Articular cartilage is susceptible to damage; however, it has limited capacity for repair. Damage can lead to persistent symptoms including pain, swelling, and loss of function and may ultimately progress to symptomatic degeneration of the joint. To restore function and minimize symptoms, many advocate surgical intervention in selected candidates, which can range from arthroscopic debridement t...

BACKGROUND The optimal treatment for cartilage lesions has not yet been established. The objective of this randomized trial was to compare autologous chondrocyte implantation with microfracture. This paper represents an update, with presentation of the clinical results at five years. METHODS Eighty patients who had a single chronic symptomatic cartilage defect on the femoral condyle in a stab...

Current approaches to treat osteoarthritis (OA) are insufficient. Autologous chondrocyte implantation (ACI) has been used for the past decade to treat patients with OA or focal cartilage defects. However, a number of complications have been reported post-ACI, including athrofibrosis and symptomatic hypertrophy. Thus, a long-term ACI strategy should ideally incorporate methods to ‘prime’ autolog...

©2006 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.88B4. 17060 $2.00 J Bone Joint Surg [Br] 2006; 88-B:421-6. The management of large bony defects and cartilage loss continues to be a challenge to trauma and orthopaedic surgeons. The treatment of these conditions has evolved over the years and has comprised of many techniques, such as autologous bone grafting, distr...