it is now well documented that interferon gamma (ifn-γ) is the indispensable cytokine for inducing protective immunity against experimental and human cutaneous leishmaniaisis. the importance of ifn-γ receptor (ifn-γr) has also been studied. in the present study, we made attempts to find out whether l. major infection is able to alter the expression of ifn-γr in vivo. in addition, we studied the...

objective(s) leishmania can lead to a broad spectrum of diseases, collectively known as leishmaniasis. the a2 gene/ protein family could be one of the most eligible candidate factors of virulence in visceral leishmaniasis (vl). the previous results confirmed that in leishmania infantum, several a2 proteins are abundantly expressed by the amastigote, but not the promastigote stage. as there are ...

background: although pentavalent antimony compounds are used as antileish-manial drugs but they are associated with limitations and several adverse complica-tions. therefore, always effort to find a new and effective treatment is desired. in this study, the effect of zno nanoparticles with mean particle size of 20 nanome-ters (nm) on leishmania major promastigotes and amastigotes was evaluated....

background: the aim of this study was to investigate the effects of leishmania major infection on the induction of oxidative stress in skin and lung of female mice. methods: balb/c mice were randomly divided into the control and experi-mental groups. the experimental groups were subcutaneously infected with in-oculums promastigotes of l. major . the animals were sacrificed at 20, 40, 60, 90 and...

background: leishmaniasis is a parasitic disease caused by different species of leishmania parasites with a wide range of clinical manifestations . antimonial compounds such as meglumine antimoniate (glucantime) are the first line drugs for the treatment of leishmaniasis. however, according to reports of the drug resistance of parasites, the efficacy of antimonial compounds is low. the atp-bind...

background: cutaneous leishmaniasis (cl) is one of the most important health problems in different regions of iran that occurs both in zoonotic and anthroponotic forms in different foci of iran. the khuzistan province, located in the south west of iran in vicinity of the persian gulf, is one of the oldest susceptible foci for cl in iran. objectives: due to the lack of information about the cond...

Skeletal muscle is a major component of the human body. Age-related loss of muscle mass and function contributes to some public health problems such as sarcopenia and osteoporosis. Skeletal muscle, mainly composed of appendicular lean mass (ALM), is a heritable trait. Copy number variation (CNV) is a common type of human genome variant which may play an important role in the etiology of many hu...

We report a transient expression transfection system in Leishmania enriettii. A hybrid gene containing an intergenic region of the alpha-tubulin cluster and the bacterial chloramphenicol acetyltransferase (CAT; EC 2.3.1.28) gene is expressed after transfection of L. enriettii with the hybrid plasmid. The expression of the CAT gene is dependent on the presence of sequences from the alpha-tubulin...