Strategies for antibody-mediated cancer immunotherapy, such as active immunization with virus-like particle (VLP)-based vaccines, are gaining increasing attention. We developed chimeric hepatitis B virus core antigen (HBcAg)-VLPs that display a surface epitope of the highly selective tumor-associated cell lineage marker claudin-18 isoform 2 (CLDN18.2) flanked by a mobility-increasing linker. Au...

OBJECTIVE Auto-antibodies to signal recognition particle (SRP) are known to be specific to PM among rheumatic disorders, but the specificity in myopathic diseases remains unclear. The clinical utility of anti-SRP antibody in the differential diagnosis of myopathies has not been studied. The aim of the present study was to elucidate whether detection of anti-SRP antibody can discriminate of PM f...

p ATIENTS with acquired auto-immune hemolytic anemia associated with a decreased red cell production have been reported by several authors.1-5 We have observed such cases among patients with acquired auto-immune hemolytic anemia due to incomplete antibodies of the warm variety. There have been many reports6 ’ suggesting the sensitization and damages of erythroblasts in the bone marrow by anti-e...

Hyperthyroidism can be defined as the status of over production thyroid hormones: tri-iodothyronine (T3) and thyroxine (T4) a results gland dysfunction. The aim current study was to investigate association between abnormalities hormones (T3 T4) serum levels auto-antibodies: anti-thyroid peroxidase (TPO-Ab) stimulating hormone receptor (TR-Ab) state hyperthyroidism. Blood samples were collected ...

Studies suggest certain stimuli like apoptosis behind the aberrant expression of circulating specific auto-antibodies in Type-1 diabetic patients. In present study, we investigated whether Streptozotocin (a diabetogenic compound) induced Rat RINm5f Insulinoma cells can expose immunogenic cryptic antigens. A time course treatment with 4 mM revealed 6hrs as minimal period to induce without much e...

The relationship between autoimmunity and malaria is not well understood. To determine whether autoimmune responses have a protective role during malaria, we studied the pattern of reactivity to plasmodial antigens of sera from 93 patients with 14 different autoimmune diseases (AID) who were not previously exposed to malaria. Sera from patients with 13 different AID reacted against Plasmodium f...

Background: Premature ovarian failure (POF) is a disorder of multi causal etiology. Autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in POF. The aim of this study was to identify the level of auto-antibodies in POF and familial POF patients. Materials and Methods: In this study, auto-antibodies including anti-ovarian antibody (AOA), a...