Sustainable aquaculture, from both ecological and economic perspectives, demands a substantial reduction of the amount of fishmeal used in aqua feed. Instead, plant-derived protein feed stuff, which provide a nutritious diet offer a promising alternative for inclusion in aqua feed. In this study, the effects of organic selenium supplementation in low and high soybean meal-based practical diets ...

Background The RAS/MAPK pathway has emerged as a critical for therapeutic targeting in spectrum of solid tumor and hematological malignances. Inhibitors MAPK targets, such RAS, BRAF, or MEK have been approved the treatment cancer either monotherapy combination. However, there no drug ERK1/2, terminal kinases Ras-Raf-MEK-ERK signal transduction cascade. combination ERK1/2 inhibitor checkpoint in...

Figure 1 shows a simplified picture of the information infrastructure of my library. It is by no means something special: I suppose any university library, or at least many of them can show similar pictures. What is special is that 80% of it did not exist 10 years ago. What the library usually is identified with is this little part in the lower left side of the chart: the catalogue, representin...

Background Programmed death-ligand 1 (PD-L1) and programmed cell death protein 1(PD-1) blockade therapy has revolutionized the treatment landscape of malignancies. However, only a minority patients are anticipated to experience deep durable response. In addition, successful therapeutic agonism 4-1BB, promising co-stimulatory immunologic target, been limited by major safety concerns hepatotoxici...

and Applied Analysis 3 When a 0, we set s dp∗ 0, d and t bp∗ 0, b , then 1.1 is equivalent to the following quasilinear elliptic equations: −div ( |∇u|p−2∇u ) − μ |u| p−2u |x| |u|p t −2u |x| λ |u|q−2u |x| in Ω, u 0 on ∂Ω, 1.7 where λ > 0, 1 < p < N, 0 ≤ μ < μ N − p /p , 0 ≤ s, t < p, 1 ≤ q < p and p∗ t p N − t / N − p . Such kind of problem relative with 1.7 has been extensively studied by many...

Background: Recently introduced antipsychotic and antidepressant drugs may have advantages over older drugs but their high cost may be a major limitation to their availability. Anecdotal reports have described large differences between costs for these drugs in the US and other countries. Methods: Physicians and pharmacists from 17 countries in North America and Europe provided information on th...

O n e o f a listener's major tasks in understanding co n t in u o u s speech is seg m en tin g the speech signal into separate words. W hen listening con d it ion s are difficult, speakers can help listeners by deliberate ly speak ing m ore clearly. In four exp er im en ts , we ex a m in ed h ow word boundaries are produced in deliberate ly clear sp eech . D urational m easu rem en ts were take...

O n e o f a listener's major tasks in understanding co n t in u o u s speech is seg m en tin g the speech signal into separate words. W hen listening con d it ion s are difficult, speakers can help listeners by deliberate ly speak ing m ore clearly. In four exp er im en ts , we ex a m in ed h ow word boundaries are produced in deliberate ly clear sp eech . D urational m easu rem en ts were take...