OBJECTIVE To study adjustment strategies in unilateral amputees in uphill and downhill walking. DESIGN Observational cohort study. SUBJECTS Seven transfemoral, 12 transtibial unilateral amputees and 10 able-bodied subjects. METHODS In a motion analysis laboratory the subjects walked over a level surface and an uphill and downhill slope. Gait velocity and lower limb joint angles were measu...

This study examined the effects of sprint running training on sloping surfaces (3°) in experienced sprinters using selected kinematic variables. Twelve experienced sprinters were randomly allocated to two training groups (combined uphill–downhill and horizontal). Preand post-training tests were performed to examine the effects of six weeks of training on maximum running speed, step rate, step l...

BACKGROUND Proximal or 'downhill' esophageal varices are a rare cause of upper gastrointestinal hemorrhage. Unlike the much more common distal esophageal varices, which are most commonly a result of portal hypertension, downhill esophageal varices result from vascular obstruction of the superior vena cava (SVC). While SVC obstruction is most commonly secondary to malignant causes, our review of...

We introduce a filter mechanism to force convergence for augmented Lagrangian methods for nonlinear programming. In contrast to traditional augmented Lagrangian methods, our approach does not require the use of forcing sequences that drive the first-order error to zero. Instead, we employ a filter to drive the optimality measures to zero. Our algorithm is flexible in the sense that it allows fo...

The synthetic control method (SCM) is a popular approach for estimating the impact of treatment on single unit in panel data settings. “synthetic control” weighted average units that balances treated unit’s pretreatment outcomes and other covariates as closely possible. A critical feature original proposal to use SCM only when fit excellent. We propose Augmented an extension settings where such...

Brain cytokines, induced by various inflammatory challenges, have been linked to sickness behaviors, including fatigue. However, the relationship between brain cytokines and fatigue after exercise is not well understood. Delayed recovery of running performance after muscle-damaging downhill running is associated with increased brain IL-1beta concentration compared with uphill running. However, ...

Motivated by the observed time scales in protein systems said to fold "downhill," we have studied the finite, linear master equation, with uniform rates forward and backward as a model of the downhill process. By solving for the system eigenvalues, we prove the claim that in situations where there is no free energy barrier a transition between single- and multi-exponential kinetics occurs at su...