Auditory pattern changes have been shown to elicit increases in magnetoencephalographic gamma-band activity (GBA) over left inferior frontal cortex, forming part of the putative auditory ventral "what" processing stream. The present study employed a McGurk-type paradigm to assess whether GBA would be associated with subjectively perceived changes even when auditory stimuli remain unchanged. Mag...

The P3 component of the event-related potential (ERP) is generated in humans and other mammalian species when attention is drawn to infrequent stimuli. We assessed the role of subregions of human posterior association cortex in auditory P3 generation in groups of patients with focal cortical lesions. Auditory P3s were recorded to target (P3b) and unexpected novel stimuli (P3a) in monaural and d...

Congenital deafness causes large changes in the auditory cortex structure and function, such that without early childhood cochlear-implant, profoundly deaf children do not develop intact, high-level, auditory functions. But how is auditory cortex organization affected by congenital, prelingual, and long standing deafness? Does the large-scale topographical organization of the auditory cortex de...

A "ventral" auditory pathway in nonhuman primates that originates in the core auditory cortex and ends in the prefrontal cortex is thought to be involved in components of nonspatial auditory processing. Previous work from our laboratory has indicated that neurons in the prefrontal cortex reflect monkeys' decisions during categorical judgments. Here, we tested the role of the superior temporal g...

Sensory systems influence one another during development and deprivation can lead to cross-modal plasticity. As auditory function begins before vision, we investigate the effect of manipulating visual experience during auditory cortex critical periods (CPs) by assessing the influence of early, normal and delayed eyelid opening on hearing loss-induced changes to membrane and inhibitory synaptic ...

respond preferentially to complex sounds (e.g., bandOur understanding of the visual system has benefited pass noise or species-specific vocalizations) relative to markedly from the hypothesis that visual processing tones. In contrast, neurons in the core region respond occurs in two separate streams—one for what (or who) preferentially to tones relative to complex sounds. It is and one for wher...

In informational masking paradigms, the successful segregation between target and masker creates auditory perceptual awareness. The dynamics of build-up perception is based on a set interactions bottom–up top–down processes that generate neuronal modifications within brain network activity. These neural changes are studied here using event-related potentials (ERPs), entropy, integrated informat...

Human faces contain multiple sources of information. During speech perception, visual information from the talker's mouth is integrated with auditory information from the talker's voice. By directly recording neural responses from small populations of neurons in patients implanted with subdural electrodes, we found enhanced visual cortex responses to speech when auditory speech was absent (rend...

Using high-field (3 Tesla) functional magnetic resonance imaging (fMRI), we demonstrate that auditory and somatosensory inputs converge in a subregion of human auditory cortex along the superior temporal gyrus. Further, simultaneous stimulation in both sensory modalities resulted in activity exceeding that predicted by summing the responses to the unisensory inputs, thereby showing multisensory...

How and where in the brain audio-visual signals are bound to create multimodal objects remains unknown. One hypothesis is that temporal coherence between dynamic multisensory signals provides a mechanism for binding stimulus features across sensory modalities. Here, we report that when the luminance of a visual stimulus is temporally coherent with the amplitude fluctuations of one sound in a mi...