introduction: diagnosis, prediction and control of oral lesions is usually done classically based on clinical signs and histopathologic features. due to lack of timely diagnosis in all conventional methods or differential diagnosis, biopsy of patient is needed. therefore, the patient might be irritated. so, an intelligent method for quick and accurate diagnosis would be crucial. intelligent sys...

previous studies on etiology of squamous cell carcinoma (scc) of the tongue have reported results with respect to long term exposure to cigarette smoking and alcohol abuse. the aim of this study was to investigate risk factors for scc of the tongue in a set of patients with minimum exposure to cigarette smoking and alcohol. sixty four cases with diagnosis of oral tongue scc were reviewed in thi...

background: the aberrant expression of dickkopf-1 (dkk1), triose phosphate isomerase (tpi) and fatty acid binding-protein 5 (fabp5) in lung cancer tissues and their presence in secretome of lung cancer cell lines were reported. here, serum levels of these molecules in lung cancer patients were compared to those in a healthy control group. materials and methods: the patients’ group consisted of ...

abstract background: esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. this may be due to increasing rates of barrett’s esophagus, gastroesophageal reflux, smoking and obesity. this study was performed from 1991 to 2005 in order to evaluate variou...

background and aim: squamous cell carcinoma is the eighth common cancer and forms 94% of oral malignancies. nowadays, many molecular and genetic changes have been known to affect tumoral behavior which might be good for drug production and gene therapy. it has been known that mutated p53, overexpression of p63 as an oncogene and hpv infection are correlated with clinicopathological behavior of ...

telomerase activation is one of the main pathways to immortalize cancer cells. in many kinds of cancer cells, this special reverse transcriptase stabilizes and elongates telomeres and prevents telomere erosion that naturally occurs in every cell division. esophageal cancer is the fifth most frequent cause of cancer death worldwide, and is highly associated with alcohol, smoking, cultural habits...

Malignant melanoma is known for its protean cytomorphological features, architectural patterns, and stromal changes, in addition to its ability to mimic various benign and malignant non-melanocytic tumours. Anecdotal cases of metastatic malignant melanoma simulating soft tissue sarcomas have been reported. Interestingly, this mimicry is more often seen in recurrent lesions and metastatic deposi...

Objective: The high number of smear tests has a workload on pathologists/cytopathologists, which raises the concern for quality diagnoses. application high-risk human papillomavirus (hr-HPV) analyses with PAP begun to contribute clinical practice. In this study, we aimed show effect hr-HPV analysis results via atypical squamous cell/squamous intraepithelial lesion (ASC/SIL) ratio standards. Mat...

Head and neck squamous cell carcinoma (HNSCC) is broadly classified into HNSCC associated with human papilloma virus (HPV) infection, and HPV negative HNSCC, which is typically smoking-related. A subset of HPV negative HNSCCs occur in patients without smoking history, however, and these etiologically 'atypical' HNSCCs disproportionately occur in the oral cavity, and in female patients, suggesti...

skin cancer has a broad and burdensome impact on the health and well-being of iranian and account for substantial health care costs to the nation. the first most common form of skin cancer is basal cell carcinoma (bcc); followed by the squamous cell carcinoma (scc) and the incidence of malignant melanoma (mm) is lower but is fatal. kaposi sarcoma (ks) is a tumor caused by human herpes virus 8. ...